Lack of association of Toll-like receptor 9 gene polymorphism with Behçet's disease in Japanese patients.

Lack of association of Toll-like receptor 9 gene polymorphism with Behçet's disease in Japanese patients. Research Abstract Details 

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Lack of association of Toll-like receptor 9 gene polymorphism with Behçet's disease in Japanese patients. Abstract Text:

A Ito,M Ota,Y Katsuyama,H Inoko,S Ohno,N Mizuki,A Ito,M Ota,Y Katsuyama,H Inoko,S Ohno,N Mizuki,A Ito,M Ota,Y Katsuyama,H Inoko,S Ohno,N Mizuki,

Toll-like receptors (TLRs) play an important role in the induction of defense mechanisms of the innate and adaptive immune responses to microbial pathogens. Genetic polymorphisms within the TLR9 gene have been reported to be associated with a variety of inflammatory and infectious diseases. Behçet's disease (BD) is a chronic inflammatory disease, and the etiology of BD has yet to be fully elucidated. We investigated the potential association of the TLR9 gene with susceptibility to BD by analyzing the frequency of nine single nucleotide polymorphisms (SNPs) in a population of 200 Japanese BD patients and 102 randomized controls. Our results showed that SNPs in the TLR9 gene were not significantly associated with susceptibility to BD.

Lack of association of Toll-like receptor 9 gene polymorphism with Behçet's disease in Japanese patients. Publishing Authors By Initials

A Ito,M Ota,Y Katsuyama,H Inoko,S Ohno,N Mizuki,A Ito,M Ota,Y Katsuyama,H Inoko,S Ohno,N Mizuki,A Ito,M Ota,Y Katsuyama,H Inoko,S Ohno,N Mizuki,

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Lack of association of Toll-like receptor 9 gene polymorphism with Behçet's disease in Japanese patients. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Tissue antigens

VOLUME: 70

Page Numbers: 423-6

Journal Abbreviation: Tissue Antigens

ISSN: 0001-2815

DAY: 14

MONTH: 09

YEAR: 2007

Lack of association of Toll-like receptor 9 gene polymorphism with Behçet's disease in Japanese patients. Information

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LANGUAGE: eng

NlmUniqueID: 331072

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Grant and Affiliation Information for Lack of association of Toll-like receptor 9 gene polymorphism with Behçet's disease in Japanese patients.

AFFILIATION: Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.

Country: Denmark

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MEDLINETA: Tissue Antigens

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