Lack of an association of depression with n-3 polyunsaturated fatty acids in adipose tissue and serum phospholipids in healthy adults.

Lack of an association of depression with n-3 polyunsaturated fatty acids in adipose tissue and serum phospholipids in healthy adults. Research Abstract Details 

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Lack of an association of depression with n-3 polyunsaturated fatty acids in adipose tissue and serum phospholipids in healthy adults. Abstract Text:

George Mamalakis,Michael Kiriakakis,George Tsibinos,Eugene Jansen,Hans Cremers,Carlo Strien,Christos Hatzis,Joanna Moschandreas,Manolis Linardakis,Daan Kromhout,Anthony Kafatos,

Studies have shown that depression relates to biomarkers of both short-term and long-term polyunsaturated fatty acid intake. However, it is not known which of these two biomarkers is more closely related to depression. The aim of this study was to examine the relationship of depression with both adipose tissue and serum phospholipid polyunsaturated fatty acids and to assess the importance of each of these two biomarkers in relating to depression. This is a cross-sectional study of healthy adults from the island of Crete. Subjects were examined by the Preventive Medicine and Nutrition Clinic of the University of Crete. Subjects were 394 healthy adults (175 males, 219 females) aged 18-60. The sample consisted of farmers from a number of rural communities of Crete. Fatty acids were determined by gas chromatography in adipose tissue and serum phospholipids. Information about depression was obtained through the Beck Depression Inventory (BDI) and Zung Self-rating Depression Scale (ZSRDS). Adipose tissue alpha-linolenic acid (ALA) (C18:3n-3) was inversely correlated to BDI (r=-0.17, p<0.02). Multiple linear regression analysis taking into account the possible confounding effect of age, gender, body mass index (BMI), smoking and educational level did not confirm this association. The other polyunsaturated fatty acids in adipose tissue were not related to depression. Serum phospholipid polyunsaturated fatty acids did not correlate with depression. This study did not show that the polyunsaturated fatty acids in the adipose tissue are better predictors of depression than those in serum phospholipids.

Lack of an association of depression with n-3 polyunsaturated fatty acids in adipose tissue and serum phospholipids in healthy adults. Publishing Authors By Initials

G Mamalakis,M Kiriakakis,G Tsibinos,E Jansen,H Cremers,C Strien,C Hatzis,J Moschandreas,M Linardakis,D Kromhout,A Kafatos,

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Lack of an association of depression with n-3 polyunsaturated fatty acids in adipose tissue and serum phospholipids in healthy adults. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pharmacology, biochemistry, and behavior

VOLUME: 89

Page Numbers: 6-10

Journal Abbreviation: Pharmacol. Biochem. Behav.

ISSN: 0091-3057

DAY: 30

MONTH: 10

YEAR: 2007

Lack of an association of depression with n-3 polyunsaturated fatty acids in adipose tissue and serum phospholipids in healthy adults. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Lack of an association of depression with n-3 polyunsaturated fatty acids in adipose tissue and serum phospholipids in healthy adults.

AFFILIATION: University of Crete, School of Medicine, Department of Social Medicine Preventive Medicine and Nutrition, P.O. Box 2208, 71003 Iraklion, Crete, Greece.

Country: United States

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MEDLINETA: Pharmacol Biochem Behav

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