Laccase-induced derivatization of unprotected amino acid L-tryptophan by coupling with p-hydroquinone 2,5-dihydroxy-N-(2-hydroxyethyl)-benzamide.

Laccase-induced derivatization of unprotected amino acid L-tryptophan by coupling with p-hydroquinone 2,5-dihydroxy-N-(2-hydroxyethyl)-benzamide. Research Abstract Details 

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Laccase-induced derivatization of unprotected amino acid L-tryptophan by coupling with p-hydroquinone 2,5-dihydroxy-N-(2-hydroxyethyl)-benzamide. Abstract Text:

K Manda,E Hammer,A Mikolasch,D ,K Thurow,F Schauer,K Manda,E Hammer,A Mikolasch,D ,K Thurow,F Schauer,K Manda,E Hammer,A Mikolasch,D Gördes,K Thurow,F Schauer,

We have studied the enzymatic derivatization of amino acids by use of the polyphenol oxidase laccase. Derivatization of L-tryptophan was achieved by enzymatic crosslinking with the laccase substrate 2,5-dihydroxy-N-(2-hydroxyethyl)-benzamide. The main product (yield up to 70%) was identified as the quinoid compound 2-[2-(2-hydroxy-ethylcarbamoyl)-3,6-dioxo-cyclohexa-1,4-dienylamino]-3-(1H-indol-3-yl)- propionic acid and demonstrates that laccase-catalyzed C-N-coupling occurred on the amino group of the aliphatic side chain. These enzyme based reactions provide a simple and fast method for the derivatization of unprotected amino acids.

Laccase-induced derivatization of unprotected amino acid L-tryptophan by coupling with p-hydroquinone 2,5-dihydroxy-N-(2-hydroxyethyl)-benzamide. Publishing Authors By Initials

K Manda,E Hammer,A Mikolasch,D ,K Thurow,F Schauer,K Manda,E Hammer,A Mikolasch,D ,K Thurow,F Schauer,K Manda,E Hammer,A Mikolasch,D Gördes,K Thurow,F Schauer,

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Laccase-induced derivatization of unprotected amino acid L-tryptophan by coupling with p-hydroquinone 2,5-dihydroxy-N-(2-hydroxyethyl)-benzamide. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Amino acids

VOLUME: 31

Page Numbers: 409-19

Journal Abbreviation: Amino Acids

ISSN: 0939-4451

DAY: 4

MONTH: 04

YEAR: 2006

Laccase-induced derivatization of unprotected amino acid L-tryptophan by coupling with p-hydroquinone 2,5-dihydroxy-N-(2-hydroxyethyl)-benzamide. Information

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LANGUAGE: eng

NlmUniqueID: 9200312

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Grant and Affiliation Information for Laccase-induced derivatization of unprotected amino acid L-tryptophan by coupling with p-hydroquinone 2,5-dihydroxy-N-(2-hydroxyethyl)-benzamide.

AFFILIATION: Institut für Mikrobiologie, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany.

Country: Austria

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MEDLINETA: Amino Acids

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