Laboratory markers of thrombosis risk in children with hereditary spherocytosis.

Laboratory markers of thrombosis risk in children with hereditary spherocytosis. Research Abstract Details 

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Laboratory markers of thrombosis risk in children with hereditary spherocytosis. Abstract Text:

Sarah B Troendle,Leah Adix,Shelley E Crary,George R Buchanan,

BACKGROUND: Recent data suggest that adults with hereditary spherocytosis (HS) may be protected from atherothrombosis before splenectomy but have increased risk of thrombosis following splenectomy. In order to aid in making informed decisions regarding splenectomy in children with HS, we conducted a retrospective study of several surrogate laboratory markers of thrombosis risk in children with HS. METHODS: A retrospective record review was performed on 246 children with HS. Platelet count and hemoglobin concentration were recorded prior to and following splenectomy in each patient. Serum cholesterol levels were collected from the record when available. RESULTS: Prior to splenectomy, hypocholesterolemia was common. Mean platelet counts in 31 evaluable patients pre- and post-splenectomy were 334 and 608 x 10(9)/L, respectively (P < 0.001). Twenty-nine patients (94%) exhibited persistent thrombocytosis following splenectomy. Hemoglobin values following splenectomy often rose to higher than age and gender-matched norms, with 30% of measurements greater than the 90th percentile and 17% greater than the 97th percentile. CONCLUSIONS: The findings of hypocholesterolemia before splenectomy and thrombocytosis and mild polycythemia afterwards support the hypothesis that patients with HS might be protected from thrombosis before splenectomy and/or more susceptible afterwards. Prospective studies of additional prothrombotic biomarkers and thrombotic events in HS patients are warranted.

Laboratory markers of thrombosis risk in children with hereditary spherocytosis. Publishing Authors By Initials

SB Troendle,L Adix,SE Crary,GR Buchanan,

For similar cardiovascular diseases: vascular diseases: embolism and thrombosis: thrombosis research abstracts see: cardiovascular diseases: vascular diseases: embolism and thrombosis: thrombosis research

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MEDLINE DATE:

Laboratory markers of thrombosis risk in children with hereditary spherocytosis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pediatric blood & cancer

VOLUME: 49

Page Numbers: 781-5

Journal Abbreviation:

ISSN: 1545-5009

DAY: 3

MONTH: Nov

YEAR: 2007

Laboratory markers of thrombosis risk in children with hereditary spherocytosis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101186624

Laboratory markers of thrombosis risk in children with hereditary spherocytosis. Keywords Mesh Terms:

KEYWORDS: Thrombosis

MESH TERMS: etiology

Chemical & Substance for Abstract: Laboratory markers of thrombosis risk in children with hereditary spherocytosis. Information

Substance Name: Cholesterol

Registry Number: 57-88-5

Grant and Affiliation Information for Laboratory markers of thrombosis risk in children with hereditary spherocytosis.

AFFILIATION: Division of Hematology-Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9063, USA.

Country: United States

AGENCY: United States NCI

GRANT: T32CA009640

ACRONYM: CA

MEDLINETA: Pediatr Blood Cancer

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