Diagnosis and monitoring of Alzheimer's disease and the related dementias have long depended principally on clinical examination, especially cognitive testing. Establishment of biomarkers, which might assist in diagnosis or tracking of disease progression, would be a highly valuable addition to the care of patients. Such biomarkers are potentially available from body fluids and tissues as well as from brain imaging data. As specific disease-modifying therapies for Alzheimer's disease are developed, biomarkers may improve diagnostic accuracy and facilitate clinical trials, allowing a better gauge of treatment response. In this review, we focus on biomarkers in cerebrospinal fluid and plasma, including measurements of the proteins tau and beta-amyloid.
Laboratory biomarkers in Alzheimer's disease. Publishing Authors By Initials
Laboratory biomarkers in Alzheimer's disease. Journal Published:
PUBLICATION TYPE: Review
Journal: Current neurology and neuroscience reports
VOLUME: 7
Page Numbers: 381-7
Journal Abbreviation:
ISSN: 1528-4042
DAY: 26
MONTH: Sep
YEAR: 2007
Laboratory biomarkers in Alzheimer's disease. Information
Number of References: 50
LANGUAGE: eng
NlmUniqueID: 100931790
Laboratory biomarkers in Alzheimer's disease. Keywords Mesh Terms:
KEYWORDS: tau Proteins
MESH TERMS: cerebrospinal fluid
Chemical & Substance for Abstract: Laboratory biomarkers in Alzheimer's disease. Information
Substance Name: tau Proteins
Registry Number: 0
Grant and Affiliation Information for Laboratory biomarkers in Alzheimer's disease.
AFFILIATION: Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, Columbia University College of Physician & Surgeons, 630 West 168th Street, New York, NY 10032, USA.
Country: United States
AGENCY: United States NIA
GRANT: P50-AG 08702
ACRONYM: AG
MEDLINETA: Curr Neurol Neurosci Rep
REFSOURCE:
DATABASENAME:
ACCESSION NUMBER:
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