L3MBTL1, a histone-methylation-dependent chromatin lock.

L3MBTL1, a histone-methylation-dependent chromatin lock. Research Abstract Details 

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L3MBTL1, a histone-methylation-dependent chromatin lock. Abstract Text:

Patrick Trojer,Guohong Li,Robert J Sims,Alejandro Vaquero,Nagesh Kalakonda,Piernicola Boccuni,Donghoon Lee,Hediye Erdjument-Bromage,Paul Tempst,Stephen D Nimer,Yuh-Hwa Wang,Danny Reinberg,

Distinct histone lysine methylation marks are involved in transcriptional repression linked to the formation and maintenance of facultative heterochromatin, although the underlying mechanisms remain unclear. We demonstrate that the malignant-brain-tumor (MBT) protein L3MBTL1 is in a complex with core histones, histone H1b, HP1gamma, and Rb. The MBT domain is structurally related to protein domains that directly bind methylated histone residues. Consistent with this, we found that the L3MBTL1 MBT domains compact nucleosomal arrays dependent on mono- and dimethylation of histone H4 lysine 20 and of histone H1b lysine 26. The MBT domains bind at least two nucleosomes simultaneously, linking repression of transcription to recognition of different histone marks by L3MBTL1. Consistently, L3MBTL1 was found to negatively regulate the expression of a subset of genes regulated by E2F, a factor that interacts with Rb.

L3MBTL1, a histone-methylation-dependent chromatin lock. Publishing Authors By Initials

P Trojer,G Li,RJ Sims,A Vaquero,N Kalakonda,P Boccuni,D Lee,H Erdjument-Bromage,P Tempst,SD Nimer,YH Wang,D Reinberg,

For similar proteins: dna-binding proteins: retinoblastoma protein research abstracts see: proteins: dna-binding proteins: retinoblastoma protein research

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L3MBTL1, a histone-methylation-dependent chromatin lock. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell

VOLUME: 129

Page Numbers: 915-28

Journal Abbreviation: Cell

ISSN: 0092-8674

DAY: 1

MONTH: Jun

YEAR: 2007

L3MBTL1, a histone-methylation-dependent chromatin lock. Information

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LANGUAGE: eng

NlmUniqueID: 413066

L3MBTL1, a histone-methylation-dependent chromatin lock. Keywords Mesh Terms:

KEYWORDS: Retinoblastoma Protein

MESH TERMS: metabolism

Chemical & Substance for Abstract: L3MBTL1, a histone-methylation-dependent chromatin lock. Information

Substance Name: Retinoblastoma Protein

Registry Number: 0

Grant and Affiliation Information for L3MBTL1, a histone-methylation-dependent chromatin lock.

AFFILIATION: Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, 683 Hoes Lane, Piscataway, NJ 08854, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM-71166

ACRONYM: GM

MEDLINETA: Cell

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