L-Dopa infusion does not improve explicit sequence learning in Parkinson's disease.

L-Dopa infusion does not improve explicit sequence learning in Parkinson's disease. Research Abstract Details 

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L-Dopa infusion does not improve explicit sequence learning in Parkinson's disease. Abstract Text:

M Felice Ghilardi,Andrew S Feigin,Fortunato Battaglia,Giulia Silvestri,Paul Mattis,David Eidelberg,Alessandro Di Rocco,

We have recently introduced a set of sequence learning tasks that emphasize explicit learning and target anticipation and involve the activation of frontal lobes. This type of learning is impaired even in the early stages of Parkinson's disease (PD). Studies on the effects of L-Dopa on cognitive symptoms of PD have yielded controversial results. To verify whether L-Dopa acutely improves explicit sequence learning, we tested six normal subjects and seven PD patients both off-drug and during L-Dopa infusion with two tasks: SEQ, a motor task with multiple demands, where a sequence had to be learned while reaching for a targets; VSEQ, a visual task where a sequence had to be learned by attending to a visual display without moving. Motor performance was assessed with simple motor tasks. L-Dopa improved motor scores and movement speed, but had no beneficial effect on either type of sequence learning.

L-Dopa infusion does not improve explicit sequence learning in Parkinson's disease. Publishing Authors By Initials

MF Ghilardi,AS Feigin,F Battaglia,G Silvestri,P Mattis,D Eidelberg,A Di Rocco,

For similar investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research abstracts see: investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research

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MEDLINE DATE:

L-Dopa infusion does not improve explicit sequence learning in Parkinson's disease. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Parkinsonism & related disorders

VOLUME: 13

Page Numbers: 146-51

Journal Abbreviation: Parkinsonism Relat. Disord.

ISSN: 1353-8020

DAY: 20

MONTH: 10

YEAR: 2006

L-Dopa infusion does not improve explicit sequence learning in Parkinson's disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9513583

L-Dopa infusion does not improve explicit sequence learning in Parkinson's disease. Keywords Mesh Terms:

KEYWORDS: Severity of Illness Index

MESH TERMS: drug effects

Chemical & Substance for Abstract: L-Dopa infusion does not improve explicit sequence learning in Parkinson's disease. Information

Substance Name: Levodopa

Registry Number: 0

Grant and Affiliation Information for L-Dopa infusion does not improve explicit sequence learning in Parkinson's disease.

AFFILIATION: Department of Physiology & Pharmacology, CUNY Medical School at City College, City University of New York, 138th Street & Convent Avenue, New York, NY 10031, USA. liceg@sci.ccny.cuny.edu

Country: England

AGENCY: United States NINDS

GRANT: NS 35069

ACRONYM: NS

MEDLINETA: Parkinsonism Relat Disord

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