L-beta,beta-dimethylcysteine attenuates the haemodynamic responses elicited by systemic injections of peroxynitrite in anaesthetized rats.

L-beta,beta-dimethylcysteine attenuates the haemodynamic responses elicited by systemic injections of peroxynitrite in anaesthetized rats. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

L-beta,beta-dimethylcysteine attenuates the haemodynamic responses elicited by systemic injections of peroxynitrite in anaesthetized rats. Abstract Text:

1 There is direct chemical evidence that L-beta,beta-dimethylcysteine (L-penicillamine (L-PEN)) is a scavenger of peroxynitrite. The aim of this study was to determine whether L-PEN attenuates the haemodynamic responses elicited by peroxynitrite in pentobarbital-anaesthetized rats. 2 Peroxynitrite (1-20 micromol kg(-1), i.v.) elicited dose-dependent reductions in mean arterial blood pressure (MAP) and mesenteric and hindquarter vascular resistances. 3 L-PEN (2 mmol kg(-1), i.v.) elicited relatively minor but significant increases in MAP and vascular resistances. The initial reductions in MAP and vascular resistances elicited by peroxynitrite were not diminished after administration of L-PEN whereas they were much shorter in duration. As such, the total reductions in MAP and vascular resistances were markedly reduced by L-PEN. 4 The finding that L-PEN (2 mmol kg(-1), i.v.) did not affect the hypotensive or vasodilator responses elicited of the ATP-dependent potassium-channel agonist, cromakalim (3-18 microg kg(-1), i.v.), suggests that this dose of L-PEN is not a nonselective inhibitor of vasodilation. 5 These findings suggest that L-PEN may effectively scavenge peroxynitrite in vivo and/or interfere with the mechanisms by which peroxynitrite elicits its vasodilator responses.

L-beta,beta-dimethylcysteine attenuates the haemodynamic responses elicited by systemic injections of peroxynitrite in anaesthetized rats. Publishing Authors By Initials

For similar chemical actions and uses: pharmacologic actions: therapeutic uses: cardiovascular agents: vasodilator agents research abstracts see: chemical actions and uses: pharmacologic actions: therapeutic uses: cardiovascular agents: vasodilator agents research

PUBMED ID PMID:

MEDLINE DATE:

L-beta,beta-dimethylcysteine attenuates the haemodynamic responses elicited by systemic injections of peroxynitrite in anaesthetized rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: British journal of pharmacology

VOLUME: 148

Page Numbers: 7-15

Journal Abbreviation: Br. J. Pharmacol.

ISSN: 0007-1188

DAY: 3

MONTH: May

YEAR: 2006

L-beta,beta-dimethylcysteine attenuates the haemodynamic responses elicited by systemic injections of peroxynitrite in anaesthetized rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7502536

L-beta,beta-dimethylcysteine attenuates the haemodynamic responses elicited by systemic injections of peroxynitrite in anaesthetized rats. Keywords Mesh Terms:

KEYWORDS: Vasodilator Agents

MESH TERMS: pharmacology

Chemical & Substance for Abstract: L-beta,beta-dimethylcysteine attenuates the haemodynamic responses elicited by systemic injections of peroxynitrite in anaesthetized rats. Information

Substance Name: Cromakalim

Registry Number: 94470-67-4

Grant and Affiliation Information for L-beta,beta-dimethylcysteine attenuates the haemodynamic responses elicited by systemic injections of peroxynitrite in anaesthetized rats.

AFFILIATION: Department of Physiology and Pharmacology, University of Georgia, Athens, GA, USA.

Country: England

AGENCY: United States NHLBI

GRANT: HL-44546

ACRONYM: HL

MEDLINETA: Br J Pharmacol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

L-beta,beta-dimethylcysteine attenuates the haemodynamic responses elicited by systemic injections of peroxynitrite in anaesthetized rats Related Publications

• 64Cu-azabicyclo[3.2.2]nonane thiosemicarbazone complexes: radiopharmaceuticals for PET of topoisomerase II expression in tumors.
• A state space analysis of emotion and flexibility in parent-child interactions.
• Analysis of the volatile components of cheddar cheese by direct thermal desorption-GC x GC-TOF/MS.
• Brain activation when hearing one's own and others' names.
• Candida albicans biofilms produce antifungal-tolerant persister cells.
• Cardiovascular outcomes in the African American Study of Kidney Disease and Hypertension (AASK) Trial.
• Conjugating berberine to a multidrug efflux pump inhibitor creates an effective antimicrobial.
• Contemporary developments in thin-layer chromatography.
• Determinants of plasma HDL concentrations and reverse cholesterol transport.
• Dopamine innervation of the monkey mediodorsal thalamus: Location of projection neurons and ultrastructural characteristics of axon terminals.
• Environmental impacts of dredging on seagrasses: a review.
• Hip Abductor and Knee Extensor Muscle Strength of Children with and without Down Syndrome.
• Hospital disaster preparedness in Los Angeles County.
• Identification and characterization of a cell surface protein of Prevotella intermedia 17 with broad-spectrum binding activity for extracellular matrix proteins.
• Intracellular cGMP may promote Ca2+-dependent and Ca2+-independent release of catecholamines from sympathetic nerve terminals.
• L-beta,beta-dimethylcysteine attenuates the haemodynamic responses elicited by systemic injections of peroxynitrite in anaesthetized rats.
• Metal-organic complexation in the marine environment.
• Multiwire Gas Proportional Counters: Decrepit Antiques or ClassicPerformers?
• Open the door whenever opportunity knocks.
• Production of non-standard PET radionuclides and the application of radiopharmaceuticals labeled with these nuclides.
• Quality of manufacturer provided information on safety and efficacy claims for dietary supplements for colonic health.
• Recent advances in health professional training on substance abuse disorders.
• Regulation of CRAC channel activity by recruitment of silent channels to a high open-probability gating mode.
• Sex-linked congenital deafness.
• Spontaneous uterine infections are associated with elevated prostaglandin F(2)alpha metabolite concentrations in postpartum dairy cows.
• The early alcoholism treatment movement in Australia, 1859-1939.
• The relationship between plasma homocysteine, red cell folate and plasma vitamin B12 in a sample of the New South Wales Central Coast population.
• Transcranial magnetic stimulation: a possible treatment for TBI.
• Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern.
• Uterine involution and postpartum ovarian activity in Nili-Ravi buffaloes.