L-arginine administration reverses anemia associated with renal disease.

L-arginine administration reverses anemia associated with renal disease. Research Abstract Details 

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L-arginine administration reverses anemia associated with renal disease. Abstract Text:

Takahisa Tarumoto,Shigehiko Imagawa,Makoto Kobayashi,Aki Hirayama,Keiya Ozawa,Toshiro Nagasawa,

Recombinant human erythropoietin (rhEpo) has proved to be remarkably safe and effective for the treatment of anemia. Despite the use of rhEpo, concerns about its cost, the need for frequent parenteral administration, and the development of anti-Epo antibodies have prompted the development of improved agents to rescue anemia. Patients with anemia associated with renal disease are usually treated by intravenous or subcutaneous rhEpo administration; however, some patients do not respond well to rhEpo, because of the presence of Epo antibody or other unknown reasons. A new, orally administered drug is needed as an economical and effective method to treat such patients. We administered 1.3 g/day of L-arginine to 8 elderly patients with anemia associated with renal disease. All 8 patients responded to the treatment with increases in hemoglobin levels. Six of the patients showed improved renal function. There were no significant adverse effects. Our data show that oral administration of 1.3 g/day of L-arginine significantly improves Epo production and reverses anemia without adverse effects in elderly patients who have anemia associated with renal disease and are in the predialysis state of chronic renal failure.

L-arginine administration reverses anemia associated with renal disease. Publishing Authors By Initials

T Tarumoto,S Imagawa,M Kobayashi,A Hirayama,K Ozawa,T Nagasawa,

For similar diagnosis: laboratory techniques and procedures: hematologic tests: blood cell count: erythrocyte count: reticulocyte count research abstracts see: diagnosis: laboratory techniques and procedures: hematologic tests: blood cell count: erythrocyte count: reticulocyte count research

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L-arginine administration reverses anemia associated with renal disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of hematology

VOLUME: 86

Page Numbers: 126-9

Journal Abbreviation: Int. J. Hematol.

ISSN: 0925-5710

DAY: 30

MONTH: Aug

YEAR: 2007

L-arginine administration reverses anemia associated with renal disease. Information

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LANGUAGE: eng

NlmUniqueID: 9111627

L-arginine administration reverses anemia associated with renal disease. Keywords Mesh Terms:

KEYWORDS: Reticulocyte Count

MESH TERMS: drug therapy

Chemical & Substance for Abstract: L-arginine administration reverses anemia associated with renal disease. Information

Substance Name: Arginine

Registry Number: 74-79-3

Grant and Affiliation Information for L-arginine administration reverses anemia associated with renal disease.

AFFILIATION: Division of Hematology, Department of Medicine, Jichi Medical School, Shimotsuke, Japan.

Country: United States

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MEDLINETA: Int J Hematol

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