Kv1.4 subunit expression is decreased in neurons of painful human pulp.

Kv1.4 subunit expression is decreased in neurons of painful human pulp. Research Abstract Details 

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Kv1.4 subunit expression is decreased in neurons of painful human pulp. Abstract Text:

Jason E Wells,Edward T Rose,Kevin C Rowland,John F Hatton,

Kv1.4, a subunit of voltage-gated K(+) channels, plays a large role in regulating neuronal excitability. The level of Kv1.4 expression is unknown in human sensory neurons innervating healthy or painful tissue. Therefore, we examined Kv1.4 immunoreactivity in axons innervating both clinically diagnosed asymptomatic and painful symptomatic human tooth pulp. Antibodies directed against Kv1.4 and PGP9.5, a protein marker for axons, was used to determine the proportion of PGP9.5 immunopositive tissue that was also immunopositive for Kv1.4. We report that on pulpal axons innervating symptomatic teeth Kv1.4 immunoreactivity, a correlate of decreased Kv1.4 expression, is significantly decreased (p < 0.0001), suggestive of a factor responsible for facilitating chronic dental pain and decreases in currents produced, such as I(A), in neurons innervating painful pulp.

Kv1.4 subunit expression is decreased in neurons of painful human pulp. Publishing Authors By Initials

JE Wells,ET Rose,KC Rowland,JF Hatton,

For similar stomatognathic diseases: tooth diseases: toothache research abstracts see: stomatognathic diseases: tooth diseases: toothache research

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Kv1.4 subunit expression is decreased in neurons of painful human pulp. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of endodontics

VOLUME: 33

Page Numbers: 827-9

Journal Abbreviation:

ISSN: 0099-2399

DAY: 2

MONTH: 05

YEAR: 2007

Kv1.4 subunit expression is decreased in neurons of painful human pulp. Information

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LANGUAGE: eng

NlmUniqueID: 7511484

Kv1.4 subunit expression is decreased in neurons of painful human pulp. Keywords Mesh Terms:

KEYWORDS: Toothache

MESH TERMS: metabolism

Chemical & Substance for Abstract: Kv1.4 subunit expression is decreased in neurons of painful human pulp. Information

Substance Name: Kv1.4 Potassium Channel

Registry Number: 0

Grant and Affiliation Information for Kv1.4 subunit expression is decreased in neurons of painful human pulp.

AFFILIATION: Southern Illinois University, School of Dental Medicine, Alton, Illinois 62002, USA. jwells@siue.edu

Country: United States

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MEDLINETA: J Endod

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