Ku: a multifunctional protein involved in telomere maintenance.

Ku: a multifunctional protein involved in telomere maintenance. Research Abstract Details 

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Ku: a multifunctional protein involved in telomere maintenance. Abstract Text:

Timothy S Fisher,Virginia A Zakian,

The DNA-binding protein Ku plays a critical role in a variety of cellular processes, including the repair of double-stranded DNA breaks and V(D)J recombination. Paradoxically, while Ku is required for double-stranded break repair by non-homologous end-joining, in many organisms, Ku is also associated with telomeres. Although telomeres are naturally occurring double-stranded DNA breaks, one of their first identified functions is to protect chromosomes from end-to-end fusions, a process that is promoted by non-homologous end-joining. While located at telomeres, Ku appears to play several important roles, including: (1) regulating telomere addition, (2) protecting telomeres from recombination and nucleolytic degradation, (3) promoting transcriptional silencing of telomere-proximal genes and (4) nuclear positioning of telomeres. Here, we review the role of Ku at telomeres in the model organism, Saccharomyces cerevisiae and compare and contrast it to the roles of Ku at telomeres in other organisms.

Ku: a multifunctional protein involved in telomere maintenance. Publishing Authors By Initials

TS Fisher,VA Zakian,

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Ku: a multifunctional protein involved in telomere maintenance. Journal Published:

PUBLICATION TYPE: Review

Journal: DNA repair

VOLUME: 4

Page Numbers: 1215-26

Journal Abbreviation: DNA Repair (Amst.)

ISSN: 1568-7864

DAY: 24

MONTH: 06

YEAR: 2005

Ku: a multifunctional protein involved in telomere maintenance. Information

Number of References: 96

LANGUAGE: eng

NlmUniqueID: 101139138

Ku: a multifunctional protein involved in telomere maintenance. Keywords Mesh Terms:

KEYWORDS: Telomere

MESH TERMS: physiology

Chemical & Substance for Abstract: Ku: a multifunctional protein involved in telomere maintenance. Information

Substance Name: DNA Helicases

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for Ku: a multifunctional protein involved in telomere maintenance.

AFFILIATION: Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

Country: Netherlands

AGENCY: United States NIGMS

GRANT: GM43265

ACRONYM: GM

MEDLINETA: DNA Repair (Amst)

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