Kruppel-like factor 4 regulates endothelial inflammation.

Kruppel-like factor 4 regulates endothelial inflammation. Research Abstract Details 

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Kruppel-like factor 4 regulates endothelial inflammation. Abstract Text:

Anne Hamik,Zhiyong Lin,Ajay Kumar,Mercedes Balcells,Sumita Sinha,Jonathan Katz,Mark W Feinberg,Robert E Gerzsten,Elazer R Edelman,Mukesh K Jain,

The vascular endothelium plays a critical role in vascular homeostasis. Inflammatory cytokines and non-laminar blood flow induce endothelial dysfunction and confer a pro-adhesive and pro-thrombotic phenotype. Therefore, identification of factors that mediate the effects of these stimuli on endothelial function is of considerable interest. Kruppel-like factor 4 expression has been documented in endothelial cells, but a function has not been described. In this communication we describe the expression in vitro and in vivo of Kruppel-like factor 4 in human and mouse endothelial cells. Furthermore, we demonstrate that endothelial Kruppel-like factor 4 is induced by pro-inflammatory stimuli and shear stress. Overexpression of Kruppel-like factor 4 induces expression of multiple anti-inflammatory and anti-thrombotic factors including endothelial nitric-oxide synthase and thrombomodulin, whereas knockdown of Kruppellike factor 4 leads to enhancement of tumor necrosis factor alpha-induced vascular cell adhesion molecule-1 and tissue factor expression. The functional importance of Kruppel-like factor 4 is verified by demonstrating that Kruppel-like factor 4 expression markedly decreases inflammatory cell adhesion to the endothelial surface and prolongs clotting time under inflammatory states. Kruppel-like factor 4 differentially regulates the promoter activity of pro- and anti-inflammatory genes in a manner consistent with its anti-inflammatory function. These data implicate Kruppel-like factor 4 as a novel regulator of endothelial activation in response to pro-inflammatory stimuli.

Kruppel-like factor 4 regulates endothelial inflammation. Publishing Authors By Initials

A Hamik,Z Lin,A Kumar,M Balcells,S Sinha,J Katz,MW Feinberg,RE Gerzsten,ER Edelman,MK Jain,

For similar cardiovascular diseases: vascular diseases: vasculitis research abstracts see: cardiovascular diseases: vascular diseases: vasculitis research

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Kruppel-like factor 4 regulates endothelial inflammation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of biological chemistry

VOLUME: 282

Page Numbers: 13769-79

Journal Abbreviation:

ISSN: 0021-9258

DAY: 5

MONTH: 03

YEAR: 2007

Kruppel-like factor 4 regulates endothelial inflammation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985121

Kruppel-like factor 4 regulates endothelial inflammation. Keywords Mesh Terms:

KEYWORDS: Vasculitis

MESH TERMS: pathology

Chemical & Substance for Abstract: Kruppel-like factor 4 regulates endothelial inflammation. Information

Substance Name: Nos3 protein, mouse

Registry Number: EC 1.14.13.39

Grant and Affiliation Information for Kruppel-like factor 4 regulates endothelial inflammation.

AFFILIATION: Cardiovascular Research Institute, Case Western Reserve University, Cleveland, Ohio 44106-7290, USA.

Country: United States

AGENCY: United States PHS

GRANT: T32 HOLKO 760420

ACRONYM: HL

MEDLINETA: J Biol Chem

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