Knockout mice reveal that the angiotensin II type 1B receptor links to smooth muscle contraction.

Knockout mice reveal that the angiotensin II type 1B receptor links to smooth muscle contraction. Research Abstract Details 

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Knockout mice reveal that the angiotensin II type 1B receptor links to smooth muscle contraction. Abstract Text:

Albert N Swafford,Lisa M Harrison-Bernard,Gregory M Dick,

BACKGROUND: Rodents express two isoforms of the angiotensin II type 1 (AT(1)) receptor: AT(1A) and AT(1B). It is unclear which receptor subtype mediates contraction in response to angiotensin II in various arteries. We tested the hypothesis that the AT(1B) receptor is the predominant receptor that mediates contraction in the abdominal aorta in response to angiotensin II. METHODS: Isometric tension responses to angiotensin II were determined in abdominal aortic rings obtained from male wild-type and AT(1B) receptor knockout mice. The rings were suspended in an organ bath of a wire myograph and contractions to angiotensin II and other vasoconstrictors were determined. RESULTS: Angiotensin II contracted aortic segments from wild-type mice; however, this response was virtually absent in rings obtained from AT(1B) receptor knockout mice. Contractions in response to K(+) and U46619 (thromboxane A(2) mimetic) were not different between rings obtained from wild-type and AT(1B) receptor knockout mice. CONCLUSIONS: Reduced angiotensin II contraction is not related to a generalized decrease in smooth muscle function, rather it is specifically due to genetic ablation of the AT(1B) receptor. Our data support the concept that AT(1B) receptors couple to contraction in the mouse abdominal aorta, a function that parallels the single known AT(1) receptor in human vascular smooth muscle.

Knockout mice reveal that the angiotensin II type 1B receptor links to smooth muscle contraction. Publishing Authors By Initials

AN Swafford,LM Harrison-Bernard,GM Dick,

For similar chemical actions and uses: pharmacologic actions: therapeutic uses: cardiovascular agents: vasoconstrictor agents research abstracts see: chemical actions and uses: pharmacologic actions: therapeutic uses: cardiovascular agents: vasoconstrictor agents research

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Knockout mice reveal that the angiotensin II type 1B receptor links to smooth muscle contraction. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of hypertension : journal of the

VOLUME: 20

Page Numbers: 335-7

Journal Abbreviation: Am. J. Hypertens.

ISSN: 0895-7061

DAY: 3

MONTH: Mar

YEAR: 2007

Knockout mice reveal that the angiotensin II type 1B receptor links to smooth muscle contraction. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8803676

Knockout mice reveal that the angiotensin II type 1B receptor links to smooth muscle contraction. Keywords Mesh Terms:

KEYWORDS: Vasoconstrictor Agents

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Knockout mice reveal that the angiotensin II type 1B receptor links to smooth muscle contraction. Information

Substance Name: 15-Hydroxy-11 alpha,9 alpha-(epoxymethan

Registry Number: 76898-47-0

Grant and Affiliation Information for Knockout mice reveal that the angiotensin II type 1B receptor links to smooth muscle contraction.

AFFILIATION: Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana.

Country: United States

AGENCY: United States NIDDK

GRANT: R01DK062003

ACRONYM: DK

MEDLINETA: Am J Hypertens

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