Knee loading dynamically alters intramedullary pressure in mouse femora.

Knee loading dynamically alters intramedullary pressure in mouse femora. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Knee loading dynamically alters intramedullary pressure in mouse femora. Abstract Text:

Ping Zhang,Min Su,Yunlong Liu,Andrew Hsu,Hiroki Yokota,

Dynamic mechanical loads have been known to stimulate bone formation. Many biophysical factors such as number of daily loading cycles, bone strain, strain-induced interstitial fluid flow, molecular transport, and modulation of intramedullary pressure have been considered as potential mediators in mechanotransduction of bone. Using a knee loading modality that enhances anabolic responses in mouse hindlimb, we addressed a question: Do oscillatory loads applied to the knee induce dynamic alteration of intramedullary pressure in the femoral medullary cavity? To answer this question, mechanical loads were applied to the knee with a custom-made piezoelectric loader and intramedullary pressure in the femoral medullary cavity was measured with a fiber optic pressure sensor. We observed that in response to sinusoidal forces of 0.5 Hz and 10 Hz, pressure amplitude increased up to 4-N loads and reached a plateau at 130 Pa. This amplitude significantly decreased with a loading frequency above 20 Hz. To confirm alteration of intramedullary pressure, real-time motion of microparticles in a glass tube inserted to the femoral medullary cavity ex vivo was visualized. Taken together, these data reveal that knee loading dynamically alters intramedullary pressure as a function of loading intensities and frequencies.

Knee loading dynamically alters intramedullary pressure in mouse femora. Publishing Authors By Initials

P Zhang,M Su,Y Liu,A Hsu,H Yokota,

For similar biomechanics: weight-bearing research abstracts see: biomechanics: weight-bearing research

PUBMED ID PMID:

MEDLINE DATE:

Knee loading dynamically alters intramedullary pressure in mouse femora. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Bone

VOLUME: 40

Page Numbers: 538-43

Journal Abbreviation: Bone

ISSN: 8756-3282

DAY: 27

MONTH: 10

YEAR: 2006

Knee loading dynamically alters intramedullary pressure in mouse femora. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8504048

Knee loading dynamically alters intramedullary pressure in mouse femora. Keywords Mesh Terms:

KEYWORDS: Weight-Bearing

MESH TERMS: physiology

Chemical & Substance for Abstract: Knee loading dynamically alters intramedullary pressure in mouse femora. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Knee loading dynamically alters intramedullary pressure in mouse femora.

AFFILIATION: Department of Biomedical Engineering Indiana University - Purdue University Indianapolis, Indianapolis, IN 46202, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: R01 AR052144-03A1

ACRONYM: AR

MEDLINETA: Bone

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Knee loading dynamically alters intramedullary pressure in mouse femora Related Publications

• Access to treatment and care associated with HIV infection among members of AIDS support groups in Thailand.
• Amphibacillus sediminis sp. nov., an endospore-forming bacterium isolated from lake sediment in Japan.
• Anesthetic management of simultaneous coronary artery bypass grafting and cardiac pheochromocytoma resection under cardiopulmonary bypass.
• Cerebral endothelial damage after severe head injury.
• Continuous spectrophotometric assays for three regulatory enzymes of the arginine biosynthetic pathway.
• Diversity and mechanisms of alkali tolerance in lactobacilli.
• Effects of surgical holes in mouse tibiae on bone formation induced by knee loading.
• Efficacy of plasma exchange therapy for Kawasaki disease intractable to intravenous gamma-globulin.
• Enzymatic characterization of 5-methylthioribose 1-phosphate isomerase from Bacillus subtilis.
• Facilitation of perceptual filling-in for spatio-temporal frequency of dynamic textures.
• Forced expression of Id2 in fetal thymic T cell progenitors allows some of their progeny to adopt NK cell fate.
• Frequency-dependent enhancement of bone formation in murine tibiae and femora with knee loading.
• Halobacillus faecis sp. nov., a spore-forming bacterium isolated from a mangrove area on Ishigaki Island, Japan.
• Henoch-Schonlein purpura presenting duodenal involvement similar to superior mesenteric artery syndrome in a girl.
• Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution.
• In vitro glucuronidation of estradiol-17beta by microsomes prepared using liver biopsy specimens from dairy cows.
• Influence of Small Eye Movement on Perceptual Filling-in Time.
• Knee loading accelerates bone healing in mice.
• Knee loading dynamically alters intramedullary pressure in mouse femora.
• Knee-loading modality drives molecular transport in mouse femur.
• Localization of a human lung adenocarcinoma susceptibility locus, possibly syntenic to the mouse Pas1 locus, in the vicinity of the D12S1034 locus on chromosome 12p11.2-p12.1.
• Long-term follow-up of busulfan, etoposide, and nimustine hydrochloride (ACNU) or melphalan as conditioning regimens for childhood acute leukemia and lymphoma.
• Modelling and identification of transcription-factor binding motifs in human chondrogenesis.
• Pelagicoccus croceus sp. nov., a novel marine member of the family Puniceicoccaceae within the phylum 'Verrucomicrobia' isolated from seagrass.
• Purification and characterization of alkaline phosphatase in cultured rat liver cells.
• Role of COX inhibition in pathogenesis of NSAID-induced small intestinal damage.
• Rubritalea spongiae sp. nov. and Rubritalea tangerina sp. nov., two carotenoid- and squalene-producing marine bacteria of the family Verrucomicrobiaceae within the phylum 'Verrucomicrobia', isolated from marine animals.
• Stress to endoplasmic reticulum of mouse osteoblasts induces apoptosis and transcriptional activation for bone remodeling.
• Toxic epidermal necrolysis in a child successfully treated with cyclosporin A and methylprednisolone.
• [Gene therapy of ALS with short interfering RNA]