Kit mutants and gastrointestinal physiology.

Kit mutants and gastrointestinal physiology. Research Abstract Details 

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Kit mutants and gastrointestinal physiology. Abstract Text:

Kenton M Sanders,Sean M Ward,

There has been considerable speculation about the function of interstitial cells of Cajal (ICC) since their discovery more than 100 years ago. It has been difficult to study these cells under native conditions, but great insights about the function of ICC have come from studies of genetic models with loss-of function mutations in the Kit signalling pathway. First it was discovered that signalling via Kit (a receptor tyrosine kinase) was vital for the development and maintenance of the ICC phenotype in gastrointestinal (GI) muscles. In compound heterozygotes (W/W(V) and Sl/Sl(d) animals), where there are partial loss-of-function mutations in Kit receptors or Kit ligand (stem cell factor), ICC failed to develop in various regions of the GI tract, but no major changes in the smooth muscle layers or enteric nervous system occurred in the absence of these cells. Animals with these mutations provided an unprecedented opportunity to understand the role of ICC in GI motor function, and it is now clear from these studies that ICC serve as: (i) pacemaker cells, generating the spontaneous electrical rhythms of the gut known as slow waves; (ii) a propagation pathway for slow waves so that large areas of the musculature can be entrained to a dominant pacemaker frequency; (iii) mediators of excitatory cholinergic and inhibitory nitrergic neural inputs from the enteric nervous system, and (iv) stretch receptors that modulate membrane potential and electrical slow wave frequency. This review describes the use of genetic models to understand the important physiological role of ICC in the GI tract.

Kit mutants and gastrointestinal physiology. Publishing Authors By Initials

KM Sanders,SM Ward,

For similar enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-tyrosine kinases: receptor protein-tyrosine kinases: proto-oncogene proteins c-kit research abstracts see: enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-tyrosine kinases: receptor protein-tyrosine kinases: proto-oncogene proteins c-kit research

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Kit mutants and gastrointestinal physiology. Journal Published:

PUBLICATION TYPE: Review

Journal: The Journal of physiology

VOLUME: 578

Page Numbers: 33-42

Journal Abbreviation: J. Physiol. (Lond.)

ISSN: 0022-3751

DAY: 9

MONTH: 11

YEAR: 2006

Kit mutants and gastrointestinal physiology. Information

Number of References: 81

LANGUAGE: eng

NlmUniqueID: 266262

Kit mutants and gastrointestinal physiology. Keywords Mesh Terms:

KEYWORDS: Proto-Oncogene Proteins c-kit

MESH TERMS: genetics

Chemical & Substance for Abstract: Kit mutants and gastrointestinal physiology. Information

Substance Name: Proto-Oncogene Proteins c-kit

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for Kit mutants and gastrointestinal physiology.

AFFILIATION: Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA. kent@unr.edu

Country: England

AGENCY: United States NIDDK

GRANT: P01 DK41315

ACRONYM: DK

MEDLINETA: J Physiol

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ACCESSION NUMBER:

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