Kinetics of synaptic transmission at ribbon synapses of rods and cones.

Kinetics of synaptic transmission at ribbon synapses of rods and cones. Research Abstract Details 

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Kinetics of synaptic transmission at ribbon synapses of rods and cones. Abstract Text:

Wallace B Thoreson,Wallace B Thoreson,

The ribbon synapse is a specialized structure that allows photoreceptors to sustain the continuous release of vesicles for hours upon hours and years upon years but also respond rapidly to momentary changes in illumination. Light responses of cones are faster than those of rods and, mirroring this difference, synaptic transmission from cones is also faster than transmission from rods. This review evaluates the various factors that regulate synaptic kinetics and contribute to kinetic differences between rod and cone synapses. Presynaptically, the release of glutamate-laden synaptic vesicles is regulated by properties of the synaptic proteins involved in exocytosis, influx of calcium through calcium channels, calcium release from intracellular stores, diffusion of calcium to the release site, calcium buffering, and extrusion of calcium from the cytoplasm. The rate of vesicle replenishment also limits the ability of the synapse to follow changes in release. Post-synaptic factors include properties of glutamate receptors, dynamics of glutamate diffusion through the cleft, and glutamate uptake by glutamate transporters. Thus, multiple synaptic mechanisms help to shape the responses of second-order horizontal and bipolar cells.

Kinetics of synaptic transmission at ribbon synapses of rods and cones. Publishing Authors By Initials

WB Thoreson,WB Thoreson,

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Kinetics of synaptic transmission at ribbon synapses of rods and cones. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Molecular neurobiology

VOLUME: 36

Page Numbers: 205-23

Journal Abbreviation: Mol. Neurobiol.

ISSN: 0893-7648

DAY: 10

MONTH: 07

YEAR: 2007

Kinetics of synaptic transmission at ribbon synapses of rods and cones. Information

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LANGUAGE: eng

NlmUniqueID: 8900963

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Grant and Affiliation Information for Kinetics of synaptic transmission at ribbon synapses of rods and cones.

AFFILIATION: Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, 4th floor, Durham Research Center, 985840 Nebraska Medical Center, Omaha, NE 68198-5840, USA. wbthores@unmc.edu

Country: United States

AGENCY: United States NEI

GRANT: EY10542

ACRONYM: EY

MEDLINETA: Mol Neurobiol

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