Kinetic study of DNA modification by phthalocyanine derivative of the oligonucleotide.

Kinetic study of DNA modification by phthalocyanine derivative of the oligonucleotide. Research Abstract Details 

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Kinetic study of DNA modification by phthalocyanine derivative of the oligonucleotide. Abstract Text:

Alexandra A Kuznetsova,Alexander A Chernonosov,Nikita A Kuznetsov,Vladimir V Koval,Dmitri G Knorre,Olga S Fedorova,

Design of chemically modified oligonucleotides for regulation of gene expression has attracted considerable attention over the last decades. One actively pursued approach involves antisense or antigene constructs carrying reactive groups, many of these based on transition metal complexes. The complexes of Co(II) with phthalocyanines are extremely good catalysts of oxidation of organic compounds with molecular oxygen and hydrogen peroxide. In this study, we have investigated the kinetics and thermodynamics of sequence-specific modification of DNA with deoxyribooligonucleotide linked to Co(II)-tetracarboxyphthalocyanine (PtcCo(II)) in the presence of H(2)O(2).

Kinetic study of DNA modification by phthalocyanine derivative of the oligonucleotide. Publishing Authors By Initials

AA Kuznetsova,AA Chernonosov,NA Kuznetsov,VV Koval,DG Knorre,OS Fedorova,

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Kinetic study of DNA modification by phthalocyanine derivative of the oligonucleotide. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioinorganic chemistry and applications

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Page Numbers: 23560

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ISSN: 1565-3633

DAY: 18

MONTH: 12

YEAR: 2006

Kinetic study of DNA modification by phthalocyanine derivative of the oligonucleotide. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Kinetic study of DNA modification by phthalocyanine derivative of the oligonucleotide.

AFFILIATION: Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.

Country: Egypt

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MEDLINETA: Bioinorg Chem Appl

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