Kinetic and functional analysis of the heparin-binding domain of fibronectin.

Kinetic and functional analysis of the heparin-binding domain of fibronectin. Research Abstract Details 

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Kinetic and functional analysis of the heparin-binding domain of fibronectin. Abstract Text:

Wonmo Kang,Sunok Park,Jun-Hyeog Jang,

We have previously shown that the heparin-binding domain of fibronectin (FN-HBD) enhances cell adhesion and proliferation of osteoblasts. Here we demonstrated that FN-HBD binds to heparin with a K(D) of 5 muM. Although, FN-HBD itself produces a modest effect on cell adhesion in the absence of central cell-binding domain (CCBD), FN-HBD significantly enhances cell adhesion and spreading activities by a cooperative mechanism of CCBD in MG63 cells (P < 0.05).

Kinetic and functional analysis of the heparin-binding domain of fibronectin. Publishing Authors By Initials

W Kang,S Park,JH Jang,

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Kinetic and functional analysis of the heparin-binding domain of fibronectin. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biotechnology letters

VOLUME: 30

Page Numbers: 55-9

Journal Abbreviation: Biotechnol. Lett.

ISSN: 0141-5492

DAY: 11

MONTH: 09

YEAR: 2007

Kinetic and functional analysis of the heparin-binding domain of fibronectin. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Kinetic and functional analysis of the heparin-binding domain of fibronectin.

AFFILIATION: Department of Biochemistry, Inha University College of Medicine, Incheon, 400-712, Korea.

Country: Netherlands

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MEDLINETA: Biotechnol Lett

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