Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.

Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP. Research Abstract Details 

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Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP. Abstract Text:

Anthony J Roecker,Paul J Coleman,Swati P Mercer,John D Schreier,Carolyn A Buser,Eileen S Walsh,Kelly Hamilton,Robert B Lobell,Weikang Tao,Ronald E Diehl,Vicki J South,Joseph P Davide,Nancy E Kohl,Youwei Yan,Lawrence C Kuo,Chunze Li,Carmen Fernandez-Metzler,Elizabeth A Mahan,Thomayant Prueksaritanont,George D Hartman,Anthony J Roecker,Paul J Coleman,Swati P Mercer,John D Schreier,Carolyn A Buser,Eileen S Walsh,Kelly Hamilton,Robert B Lobell,Weikang Tao,Ronald E Diehl,Vicki J South,Joseph P Davide,Nancy E Kohl,Youwei Yan,Lawrence C Kuo,Chunze Li,Carmen Fernandez-Metzler,Elizabeth A Mahan,Thomayant Prueksaritanont,George D Hartman,

Inspired by previous efforts in the pyrazolobenzoxazine class of KSP inhibitors, the design and synthesis of 1,4-diaryl-4,5-dihydropyrazole inhibitors of KSP are described. Crystallographic evidence of binding mode and in vivo potency data is also highlighted.

Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP. Publishing Authors By Initials

AJ Roecker,PJ Coleman,SP Mercer,JD Schreier,CA Buser,ES Walsh,K Hamilton,RB Lobell,W Tao,RE Diehl,VJ South,JP Davide,NE Kohl,Y Yan,LC Kuo,C Li,C Fernandez-Metzler,EA Mahan,T Prueksaritanont,GD Hartman,AJ Roecker,PJ Coleman,SP Mercer,JD Schreier,CA Buser,ES Walsh,K Hamilton,RB Lobell,W Tao,RE Diehl,VJ South,JP Davide,NE Kohl,Y Yan,LC Kuo,C Li,C Fernandez-Metzler,EA Mahan,T Prueksaritanont,GD Hartman,

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Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 5677-82

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 21

MONTH: 08

YEAR: 2007

Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

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Grant and Affiliation Information for Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.

AFFILIATION: Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, USA. anthony_roecker@merck.com

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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