Key role of tissue plasminogen activator in neurovascular coupling.

Key role of tissue plasminogen activator in neurovascular coupling. Research Abstract Details 

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Key role of tissue plasminogen activator in neurovascular coupling. Abstract Text:

Laibaik Park,Eduardo F Gallo,Josef Anrather,Gang Wang,Erin H Norris,Justin Paul,Sidney Strickland,Costantino Iadecola,Laibaik Park,Eduardo F Gallo,Josef Anrather,Gang Wang,Erin H Norris,Justin Paul,Sidney Strickland,Costantino Iadecola,Laibaik Park,Eduardo F Gallo,Josef Anrather,Gang Wang,Erin H Norris,Justin Paul,Sidney Strickland,Costantino Iadecola,

The increase in blood flow evoked by synaptic activity is essential for normal brain function and underlies functional brain imaging signals. Nitric oxide, a vasodilator released by NMDA receptor activation, is critical for the flow increase, but the factors linking NMDA receptor activity to nitric oxide-dependent hyperemia are poorly understood. Here, we show that tissue plasminogen activator (tPA), a serine protease implicated in NMDA receptor signaling, is required for the flow increase evoked by somatosensory stimulation. tPA acts by facilitating neuronal nitric oxide release, but this effect does not involve enhancement of NMDA currents or the associated intracellular Ca(2+) rise. Rather, the evidence suggests that tPA controls NMDA-dependent nitric oxide synthesis by influencing the phosphorylation state of neuronal nitric oxide synthase. These findings unveil a previously unrecognized role of tPA in vital homeostatic mechanisms coupling NMDA receptor signaling with nitric oxide synthesis and local cerebral perfusion.

Key role of tissue plasminogen activator in neurovascular coupling. Publishing Authors By Initials

L Park,EF Gallo,J Anrather,G Wang,EH Norris,J Paul,S Strickland,C Iadecola,L Park,EF Gallo,J Anrather,G Wang,EH Norris,J Paul,S Strickland,C Iadecola,L Park,EF Gallo,J Anrather,G Wang,EH Norris,J Paul,S Strickland,C Iadecola,

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Key role of tissue plasminogen activator in neurovascular coupling. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 105

Page Numbers: 1073-8

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 1091-6490

DAY: 14

MONTH: 01

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 7505876

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AFFILIATION: Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021.

Country: United States

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MEDLINETA: Proc Natl Acad Sci U S A

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