Ketamine attenuates glutamate-induced mechanical sensitization of the masseter muscle in human males.

Ketamine attenuates glutamate-induced mechanical sensitization of the masseter muscle in human males. Research Abstract Details 

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Ketamine attenuates glutamate-induced mechanical sensitization of the masseter muscle in human males. Abstract Text:

Brian E Cairns,Peter Svensson,Kelun Wang,Eduardo Castrillon,Steen Hupfeld,Barry J Sessle,Lars Arendt-Nielsen,Brian E Cairns,Peter Svensson,Kelun Wang,Eduardo Castrillon,Steen Hupfeld,Barry J Sessle,Lars Arendt-Nielsen,

The purpose of the present study was to determine whether glutamate-induced mechanical sensitization of the masseter muscle in human volunteers involves activation of peripheral N-methyl-D-aspartate (NMDA) receptors. Healthy male volunteers (n=18) participated in this randomized, two-session study. During each session, the volunteers received two injections into the right masseter muscle. An initial injection of glutamate (1 M, 0.2 ml) alone was followed 30 min later by a second injection of glutamate alone or glutamate combined with ketamine (10 mM). Pressure pain threshold (PPT) was assessed over the right masseter muscle at and 2 cm above the injection site, as well as over the right temporalis muscle and left masseter muscle prior to the first injection. The PPT was reassessed at all four sites every 5 min from 10 to 30 min after the second injection and once again 60 min after the second injection. Glutamate-evoked muscle pain, pain area and the sensory pain response index of the McGill pain questionnaire were all significantly reduced by co-injection of ketamine. The mean PPT values were significantly decreased by approximately 10%, 10, 15 and 25 min after injection of glutamate, but only over the site of injection. Co-injection of ketamine with glutamate also completely blocked the glutamate-induced mechanical sensitization 15 min post-injection as compared with glutamate alone. The lack of spread of mechanical sensitization outside the area of glutamate injection is consistent with the view that glutamate-induced mechanical sensitization results from a peripheral mechanism. The attenuation of glutamate-induced mechanical sensitization by ketamine suggests that this effect is mediated, in part, through activation of peripheral NMDA receptors.

Ketamine attenuates glutamate-induced mechanical sensitization of the masseter muscle in human males. Publishing Authors By Initials

BE Cairns,P Svensson,K Wang,E Castrillon,S Hupfeld,BJ Sessle,L Arendt-Nielsen,BE Cairns,P Svensson,K Wang,E Castrillon,S Hupfeld,BJ Sessle,L Arendt-Nielsen,

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Ketamine attenuates glutamate-induced mechanical sensitization of the masseter muscle in human males. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 169

Page Numbers: 467-72

Journal Abbreviation:

ISSN: 0014-4819

DAY: 16

MONTH: 11

YEAR: 2005

Ketamine attenuates glutamate-induced mechanical sensitization of the masseter muscle in human males. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 43312

Ketamine attenuates glutamate-induced mechanical sensitization of the masseter muscle in human males. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Ketamine attenuates glutamate-induced mechanical sensitization of the masseter muscle in human males. Information

Substance Name: Ketamine

Registry Number: 6740-88-1

Grant and Affiliation Information for Ketamine attenuates glutamate-induced mechanical sensitization of the masseter muscle in human males.

AFFILIATION: Orofacial Pain Laboratory, Center for Sensory-Motor Interaction, Aalborg University, 9220 Aalborg, Denmark. brcairns@interchange.ubc.ca

Country: Germany

AGENCY: United States NIDCR

GRANT: DE15420

ACRONYM: DE

MEDLINETA: Exp Brain Res

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