Ketamine: a controversial drug for neonates.

Ketamine: a controversial drug for neonates. Research Abstract Details 

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Ketamine: a controversial drug for neonates. Abstract Text:

Adnan T Bhutta,Adnan T Bhutta,

Ketamine is widely used for anesthesia and analgesia in neonates and children. It provides potent sedation, analgesia, and amnesia, a short duration of action, supporting hemodynamic and respiratory stability. Noncompetitive antagonism of NMDA receptors produces its primary therapeutic effects, but it also alters receptor function at dopaminergic, serotonergic, cholinergic, and opioidergic sites. Recent interest in ketamine stems from its potential to block excitotoxic cell death, although concerns have been raised about anesthetic neurotoxicity in neonatal animal models. The development of ketamine, its clinical profile, toxic effects in the immature brain, and future applications in neonates and children are reviewed in this article.

Ketamine: a controversial drug for neonates. Publishing Authors By Initials

AT Bhutta,AT Bhutta,

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Ketamine: a controversial drug for neonates. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Seminars in perinatology

VOLUME: 31

Page Numbers: 303-8

Journal Abbreviation: Semin. Perinatol.

ISSN: 0146-0005

DAY: 1

MONTH: Oct

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 7801132

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AFFILIATION: Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA. bhuttaadnant@uams.edu

Country: United States

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MEDLINETA: Semin Perinatol

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