Keishibukuryogan ameliorates glucose intolerance and hyperlipidemia in Otsuka Long-Evans Tokushima Fatty (OLETF) rats.

Keishibukuryogan ameliorates glucose intolerance and hyperlipidemia in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Research Abstract Details 

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Keishibukuryogan ameliorates glucose intolerance and hyperlipidemia in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Abstract Text:

Takako Nakagawa,Hirozo Goto,Ghazi Hussein,Hiroaki Hikiami,Naotoshi Shibahara,Yutaka Shimada,Takako Nakagawa,Hirozo Goto,Ghazi Hussein,Hiroaki Hikiami,Naotoshi Shibahara,Yutaka Shimada,

Keishibukuryogan, one of the traditional herbal formulations, is used clinically to improve blood circulation. In this study, we examined the effects of keishibukuryogan on glucose and lipids metabolism in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes. Forty-five-week-old male OLETF rats were divided into three groups: diabetic control rats given a standard chow; diabetic rats given keishibukuryogan (3%, w/w in chow); diabetic rats given pioglitazone (0.01%, w/w in chow). Oral administration of keishibukuryogan produced significant improvement against impaired glucose tolerance. On the other hand, fasting serum glucose and insulin levels, and the homeostasis index of insulin resistance did not change by keishibukuryogan treatment. Against lipid parameters, keishibukuryogan significantly lowered serum total cholesterol and triglyceride levels, and the hepatic total cholesterol level. Keishibukuryogan treatment also significantly reduced the serum leptin level, but it had no effect on the serum adiponectin level. Additionally, keishibukuryogan showed significant effects on epididymal adipose tissue by decreasing the size of fat cells and on skeletal muscle by reducing TNF-alpha protein content. From these results, it was suggested that keishibukuryogan exerts beneficial effects on the features associated with type 2 diabetes.

Keishibukuryogan ameliorates glucose intolerance and hyperlipidemia in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Publishing Authors By Initials

T Nakagawa,H Goto,G Hussein,H Hikiami,N Shibahara,Y Shimada,T Nakagawa,H Goto,G Hussein,H Hikiami,N Shibahara,Y Shimada,

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Keishibukuryogan ameliorates glucose intolerance and hyperlipidemia in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Diabetes research and clinical practice

VOLUME: 80

Page Numbers: 40-7

Journal Abbreviation: Diabetes Res. Clin. Pract.

ISSN: 1872-8227

DAY: 1

MONTH: 02

YEAR: 2008

Keishibukuryogan ameliorates glucose intolerance and hyperlipidemia in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Keishibukuryogan ameliorates glucose intolerance and hyperlipidemia in Otsuka Long-Evans Tokushima Fatty (OLETF) rats.

AFFILIATION: Department of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

Country: Ireland

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MEDLINETA: Diabetes Res Clin Pract

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