Keeping adenovirus away from the liver.

Keeping adenovirus away from the liver. Research Abstract Details 

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Keeping adenovirus away from the liver. Abstract Text:

Michael J Imperiale,

While adenovirus holds many advantages as a vector for gene delivery, much of its full potential has been limited by the tendency of the most commonly used vectors to target the liver upon systemic delivery, resulting in unacceptable toxicity. Recently in Cell, Waddington et al. unmasked the virus-host interactions that lead to hepatic transduction. The results point a way toward avoiding this pathway during development of future generations of adenovirus vectors.

Keeping adenovirus away from the liver. Publishing Authors By Initials

MJ Imperiale,

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Keeping adenovirus away from the liver. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cell host & microbe

VOLUME: 3

Page Numbers: 119-20

Journal Abbreviation: Cell Host Microbe

ISSN: 1934-6069

DAY: 13

MONTH: Mar

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 101302316

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Grant and Affiliation Information for Keeping adenovirus away from the liver.

AFFILIATION: Department of Microbiology and Immunology, University of Michigan Medical School, 1500 E. Medical Center Drive, 6304 Cancer Center, Ann Arbor, MI 48109, USA.

Country: United States

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MEDLINETA: Cell Host Microbe

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