Karyometry of the colonic mucosa.

Karyometry of the colonic mucosa. Research Abstract Details 

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Karyometry of the colonic mucosa. Abstract Text:

David S Alberts,Janine G Einspahr,Robert S Krouse,Anil Prasad,James Ranger-Moore,Peter Hamilton,Ayaaz Ismail,Peter Lance,Steven Goldschmid,Lisa M Hess,Michael Yozwiak,Hubert G Bartels,Peter H Bartels,David S Alberts,Janine G Einspahr,Robert S Krouse,Anil Prasad,James Ranger-Moore,Peter Hamilton,Ayaaz Ismail,Peter Lance,Steven Goldschmid,Lisa M Hess,Michael Yozwiak,Hubert G Bartels,Peter H Bartels,

OBJECTIVE: The study summarizes results of karyometric measurements in epithelial cells of the colorectal mucosa to document evidence of a field effect of preneoplastic development among patients with colorectal adenocarcinoma or adenoma. METHODS: Karyometric analyses were done on high-resolution images of histologic sections from 48 patients with colorectal adenocarcinomas and 44 patients with adenomas and on images from matching normal-appearing mucosa directly adjacent to such lesions, at a 1-cm and 10-cm distance from the lesions or from the rectal mucosa of adenoma patients, as well as from 24 healthy normal controls with no family history of colonic disease. RESULTS: The nuclei recorded in the histologically normal-appearing mucosa of patients with either colorectal adenoma or adenocarcinoma exhibited differences in karyometric features in comparison with nuclei recorded in rectal mucosa from patients who were free of a colonic lesion. These differences were expressed to the same extent in tissue adjacent to the lesions and in normal-appearing tissue as distant as the rectum. CONCLUSIONS: The nuclear chromatin pattern may serve as an integrating biomarker for a preneoplastic development. The field effect might provide an end point in chemopreventive intervention trials. (Cancer Epidemiol Biomarkers Prev 2007;16(12):2704-16).

Karyometry of the colonic mucosa. Publishing Authors By Initials

DS Alberts,JG Einspahr,RS Krouse,A Prasad,J Ranger-Moore,P Hamilton,A Ismail,P Lance,S Goldschmid,LM Hess,M Yozwiak,HG Bartels,PH Bartels,DS Alberts,JG Einspahr,RS Krouse,A Prasad,J Ranger-Moore,P Hamilton,A Ismail,P Lance,S Goldschmid,LM Hess,M Yozwiak,HG Bartels,PH Bartels,

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Karyometry of the colonic mucosa. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cancer epidemiology, biomarkers & prevention : a p

VOLUME: 16

Page Numbers: 2704-16

Journal Abbreviation: Cancer Epidemiol. Biomarkers P

ISSN: 1055-9965

DAY: 18

MONTH: Dec

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Arizona Cancer Center, College of Medicine, University of Arizona, 1515 North Campbell Avenue, Tucson, AZ 85724-5024. dalberts@azcc.arizona.edu.

Country: United States

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MEDLINETA: Cancer Epidemiol Biomarkers Pr

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