kappa-Opioid receptor stimulation contributes to aortic artery dilation through activation of K(ATP) channel in the rats.

kappa-Opioid receptor stimulation contributes to aortic artery dilation through activation of K(ATP) channel in the rats. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

kappa-Opioid receptor stimulation contributes to aortic artery dilation through activation of K(ATP) channel in the rats. Abstract Text:

Jian-Ming Pei,Mai Chen,Yao-Min Wang,Jun Wen,Yun-Long Zhu,

To investigate the relaxation effect and underlying mechanism of U50,488H (a selective kappa-opioid receptor agonist) on aorta in the rat, isolated aortic ring was perfused and the tension of the vessel was measured. It was shown: (1) kappa-opioid receptor stimulation with U50,488H relaxed rat aorta dose-dependently; (2) the relaxation effect of U50,488H on aorta was partially endothelium-dependent; (3) the relaxation effect of U50,488H was significantly attenuated in the presence of glybenclamide and glipizide, two ATP-sensitive K(+) channel (K(ATP)) blockers; and (4) the relaxation effect of U50,488H on vessel bore no relationship to muscarinic-receptor, beta-adrenoceptor, prostaglandin and nitric oxide (NO). These results indicate that kappa-opioid receptor stimulation with U50,488H relaxes the aortic artery at least partially via K(ATP) channel in the rat.

kappa-Opioid receptor stimulation contributes to aortic artery dilation through activation of K(ATP) channel in the rats. Publishing Authors By Initials

JM Pei,M Chen,YM Wang,J Wen,YL Zhu,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

kappa-Opioid receptor stimulation contributes to aortic artery dilation through activation of K(ATP) channel in the rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Sheng li xue bao : [Acta physiologica Sinica]

VOLUME: 55

Page Numbers: 91-5

Journal Abbreviation:

ISSN: 0371-0874

DAY: 25

MONTH: Feb

YEAR: 2003

kappa-Opioid receptor stimulation contributes to aortic artery dilation through activation of K(ATP) channel in the rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 20730130

kappa-Opioid receptor stimulation contributes to aortic artery dilation through activation of K(ATP) channel in the rats. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: kappa-Opioid receptor stimulation contributes to aortic artery dilation through activation of K(ATP) channel in the rats. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for kappa-Opioid receptor stimulation contributes to aortic artery dilation through activation of K(ATP) channel in the rats.

AFFILIATION: Department of Physiology, The Fourth Military Medical University, Xi an 710032; E-mail: jmpei@fmmu.edu.cn

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Sheng Li Xue Bao

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

kappa-Opioid receptor stimulation contributes to aortic artery dilation through activation of KATP channel in the rats Related Publications

• Cell signaling by imidazoline-1 receptor candidate, IRAS, and the nischarin homologue.
• Cloning and expression of xeroderma pigmentosum complementation group A cDNA and the identification of its recombinant protein.
• Modification of glycosylation reduces microvilli on rat liver epithelial cells.
• [Aberrant neuronal expression of mitotic protein, tau and Bax in the rat brain after injection of Abeta(25-35) into the amygdala]
• [Application of expressed sequence tag (EST) in parasite genome research]
• [Clinical investigation of the correlation between blood concentration of lactic acid and tissue oxygenation in severely burned patients]
• [Combined detection of K-ras mutation and CA19-9 level in plasma of patients with pancreatic cancer]
• [Comparison of endoscopic irsection and vaporization for superficial bladder cancer]
• [Construction of the prokaryotic expression vector of MTB lhp gene and its expression]
• [Diagnosis and treatment of adrenal medullary hyperplasia (with report of 8 cases)]
• [Effects of Nomega-nitro-L-arginine on photoreceptor apoptosis in inherited retinal degeneration of RCS rats]
• [Effects of lamivudine on cirrhotic patients following chronic hepatitis B]
• [Effects of terrestrial input on the harmful algal bloom area--with aluminum as an example]
• [Experimental study on human reaction of determination and performance in virtual environment]
• [Expression of core-binding factor a1 by human skin fibroblasts induced in vitro]
• [Expression of some active peptides and extracellular matrix in the in vitro cultured tissue engineering skin]
• [Investigation of resection and reconstruction procedure of high-sacra tumors]
• [Mechanism of arsenic trioxide-induced apoptosis in hepatic blastoma cells HepG2]
• [Microzooplankton herbivory during red tide-frequent-occurrence period in spring in the East China Sea]
• [Regulative effects and significance of substance P on the expression of basic fibroblast growth factor of granulation tissue fibroblasts in vitro]
• [Role of NADH-cytochrome b(5) reductase in biosynthesis of thyroid hydrogen peroxide]
• [Study of specific targeting cytotoxicity mediated by anti-CD(3)/anti-CD(20) Diabody]
• [Study on gene mutation in 11 Chinese families with Hailey-Hailey disease]
• [Study on making pneumoconiosis model and method of lung lavage in rabbit]
• [Study on the mutation of human telomeric repeat binding factor 1 gene in malignant hematopoietic cell lines]
• [Successful management of sudden respiratory and heart arrest resulting from severe closed thoracoabdominal trauma: report of one case]
• [The expression and mechanism study of BMP in pleomorphic adenoma]
• [The mutation of anti-CD3 antibody (HIT3a) gene and its expression]
• [The prevention of primary liver cancer by selenium in high risk populations]
• kappa-Opioid receptor stimulation contributes to aortic artery dilation through activation of K(ATP) channel in the rats.