Kaposi's sarcoma-associated herpesvirus lytic gene ORF57 is essential for infectious virion production.

Kaposi's sarcoma-associated herpesvirus lytic gene ORF57 is essential for infectious virion production. Research Abstract Details 

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Kaposi's sarcoma-associated herpesvirus lytic gene ORF57 is essential for infectious virion production. Abstract Text:

Zhao Han,Sankar Swaminathan,

The ORF57 gene of Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a nuclear protein expressed during the lytic phase of KSHV replication. An ORF57 homolog is present in all known human herpesviruses and many animal herpesviruses. Many of these proteins have been demonstrated to have essential transcriptional and posttranscriptional regulatory functions. ORF57 enhances expression of reporter genes posttranscriptionally in vitro and may synergize with transcription factors to enhance gene transcription. However, the biologic role of ORF57 in KSHV replication has not been established. In this study, we demonstrate that ORF57 is essential for productive KSHV lytic replication by constructing a recombinant KSHV in which ORF57 expression has been specifically inactivated. The ORF57-null KSHV recombinant was unable to produce virion progeny or fully express several other lytic KSHV genes except when ORF57 was provided in trans. The Epstein-Barr virus (EBV) homolog of ORF57, SM, was unable to rescue lytic KSHV virion production, although EBV SM does enhance KSHV lytic gene expression from the ORF57-null mutant. Conversely, ORF57 did not rescue an SM-null recombinant EBV, indicating the existence of virus-specific functions for the ORF57 family of genes.

Kaposi's sarcoma-associated herpesvirus lytic gene ORF57 is essential for infectious virion production. Publishing Authors By Initials

Z Han,S Swaminathan,

For similar viruses: virion research abstracts see: viruses: virion research

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Kaposi's sarcoma-associated herpesvirus lytic gene ORF57 is essential for infectious virion production. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of virology

VOLUME: 80

Page Numbers: 5251-60

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 3

MONTH: Jun

YEAR: 2006

Kaposi's sarcoma-associated herpesvirus lytic gene ORF57 is essential for infectious virion production. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

Kaposi's sarcoma-associated herpesvirus lytic gene ORF57 is essential for infectious virion production. Keywords Mesh Terms:

KEYWORDS: Virion

MESH TERMS: physiology

Chemical & Substance for Abstract: Kaposi's sarcoma-associated herpesvirus lytic gene ORF57 is essential for infectious virion production. Information

Substance Name: Viral Proteins

Registry Number: 0

Grant and Affiliation Information for Kaposi's sarcoma-associated herpesvirus lytic gene ORF57 is essential for infectious virion production.

AFFILIATION: Program in Cancer Genetics, Epigenetics and Tumor Virology, UF Shands Cancer Center, Box 100232, University of Florida, Gainesville, FL 32610-0232, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA81133

ACRONYM: CA

MEDLINETA: J Virol

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