Kainic acid induces long-lasting depolarizations in hippocampal neurons only when applied to stratum lucidum.

Kainic acid induces long-lasting depolarizations in hippocampal neurons only when applied to stratum lucidum. Research Abstract Details 

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Kainic acid induces long-lasting depolarizations in hippocampal neurons only when applied to stratum lucidum. Abstract Text:

S Sawada,M Higashima,C Yamamoto,

The actions of alpha-kainic acid (KA) were reexamined in thin sections of the hippocampus and the cerebellum of the guinea pig in view of various discrepancies between our previous findings and reports from other laboratories. Brief pulses of KA ejected in st. lucidum in the CA3 region induced short- and long-lasting depolarizations in neurons nearby, whereas those ejected in st. radiatum or st. oriens induced only short-lasting responses. Neurons in CA1 region and Purkinje cells in the cerebellum generated only short-lasting depolarizations in response to KA pulses ejected in their dendritic fields. The short-lasting KA responses in CA1 region were sensitive to gamma-D-glutamylglycine and pentobarbital. The slow KA responses were suppressed by kynurenic acid. They were not accompanied by increases in extracellular potassium concentration. These results suggest that the mossy fiber-innervated portions of the surface membrane of CA3 neurons have a type of KA receptor different from those ubiquitously distributed in central neurons.

Kainic acid induces long-lasting depolarizations in hippocampal neurons only when applied to stratum lucidum. Publishing Authors By Initials

S Sawada,M Higashima,C Yamamoto,

For similar nervous system: neural pathways research abstracts see: nervous system: neural pathways research

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Kainic acid induces long-lasting depolarizations in hippocampal neurons only when applied to stratum lucidum. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 72

Page Numbers: 135-40

Journal Abbreviation:

ISSN: 0014-4819

DAY: 15

MONTH: 02

YEAR: 1988

Kainic acid induces long-lasting depolarizations in hippocampal neurons only when applied to stratum lucidum. Information

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LANGUAGE: eng

NlmUniqueID: 43312

Kainic acid induces long-lasting depolarizations in hippocampal neurons only when applied to stratum lucidum. Keywords Mesh Terms:

KEYWORDS: Neural Pathways

MESH TERMS: physiology

Chemical & Substance for Abstract: Kainic acid induces long-lasting depolarizations in hippocampal neurons only when applied to stratum lucidum. Information

Substance Name: Kynurenic Acid

Registry Number: 492-27-3

Grant and Affiliation Information for Kainic acid induces long-lasting depolarizations in hippocampal neurons only when applied to stratum lucidum.

AFFILIATION: Department of Physiology, Faculty of Medicine, Kanazawa University, Japan.

Country: GERMANY, WEST

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MEDLINETA: Exp Brain Res

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