Kainate receptors and RNA editing in cholinergic neurons.

Kainate receptors and RNA editing in cholinergic neurons. Research Abstract Details 

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Kainate receptors and RNA editing in cholinergic neurons. Abstract Text:

Douglas P Olsen,Kathleen Dunlap,Michele H Jacob,

Parasympathetic ganglia are considered simple relay systems that have cholinergic input and output, with modulation occurring centrally. Greater complexity is suggested, however, by our showing here that avian ciliary ganglion (CG) neurons also express a different excitatory receptor type--ionotropic glutamate receptors of the kainate subtype (KARs). This is the first report of glutamate receptor expression in the CG and KAR expression in any cholinergic neuron. We show that KARs form functional channels on CG neurons. KARs localize to CG neuron axons and somata as well as axons and terminals of pre-synaptic inputs to the CG. Glutamate transporters are expressed on Schwann cells that surround synapses on neuronal somata, and may provide a local source of glutamate. CG neurons express multiple KAR subunit mRNAs (GluR5, GluR7, and KA1), and their relative levels change dramatically during axon outgrowth and synaptic differentiation. The developmental role for KARs may depend upon their calcium permeability, a property regulated by mRNA editing. We show GluR5 editing increases predominantly at the time CG axons contact peripheral targets. Our data suggest that glutamatergic signaling may function as a local circuit mechanism to modulate excitability and calcium signaling during synapse formation and maturation in the CG in vivo.

Kainate receptors and RNA editing in cholinergic neurons. Publishing Authors By Initials

DP Olsen,K Dunlap,MH Jacob,

For similar synaptic transmission research abstracts see: synaptic transmission research

PUBMED ID PMID:

MEDLINE DATE:

Kainate receptors and RNA editing in cholinergic neurons. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of neurochemistry

VOLUME: 101

Page Numbers: 327-41

Journal Abbreviation: J. Neurochem.

ISSN: 0022-3042

DAY: 15

MONTH: 01

YEAR: 2007

Kainate receptors and RNA editing in cholinergic neurons. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985190

Kainate receptors and RNA editing in cholinergic neurons. Keywords Mesh Terms:

KEYWORDS: Synaptic Transmission

MESH TERMS: physiology

Chemical & Substance for Abstract: Kainate receptors and RNA editing in cholinergic neurons. Information

Substance Name: Glutamic Acid

Registry Number: 56-86-0

Grant and Affiliation Information for Kainate receptors and RNA editing in cholinergic neurons.

AFFILIATION: Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.

Country: England

AGENCY: United States NINDS

GRANT: P30 NS047243

ACRONYM: NS

MEDLINETA: J Neurochem

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