Juxtaglomerular cell tumor (JGCT) is an extremely rare renal neoplasm in the pediatric population. It is considered a benign tumor arising from the juxtaglomerular apparatus of the kidney. JGCT has characteristic clinicopathologic features, but its cytogenetic features are unknown. We report a case of JGCT in an 8-year-old female who presented with severe hypertension, elevated serum renin level, and a well circumscribed tumor in the right kidney. Protogranules of renin was identified in the cytoplasm of the tumor cells by electron microscopic examination. Fluorescence in situ hybridization revealed monosomy of chromosomes X, 6, 9, 11, 15, and 21. Pediatr Blood Cancer 2008;50:406-409. (c) 2006 Wiley-Liss, Inc.
Juxtaglomerular cell tumor in an 8-year-old girl. Publishing Authors By Initials
Juxtaglomerular cell tumor in an 8-year-old girl. Journal Published:
PUBLICATION TYPE: Journal Article
Journal: Pediatric blood & cancer
VOLUME: 50
Page Numbers: 406-9
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ISSN: 1545-5017
DAY: 12
MONTH: Feb
YEAR: 2008
Juxtaglomerular cell tumor in an 8-year-old girl. Information
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LANGUAGE: eng
NlmUniqueID: 101186624
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Grant and Affiliation Information for Juxtaglomerular cell tumor in an 8-year-old girl.
AFFILIATION: Department of Pathology, Children's Mercy Hospitals and Clinics, School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri.
Country: United States
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MEDLINETA: Pediatr Blood Cancer
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