Juvenile syndecan-1 null mice are protected from carcinogen-induced tumor development.

Juvenile syndecan-1 null mice are protected from carcinogen-induced tumor development. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Juvenile syndecan-1 null mice are protected from carcinogen-induced tumor development. Abstract Text:

S P McDermott,E A Ranheim,V S Leatherberry,S S Khwaja,K S Klos,C M Alexander,

We previously showed that mice with a null mutation in syndecan-1 (Sdc1; CD138) were resistant to Wnt1-induced mammary tumor initiation. The absence of Sdc1 inhibited the increase in the mammary stem cell fraction that is characteristic of preneoplasia in this model. As the tumor precursor cells are recruited from the stem/progenitor cell compartment, tumor development was also inhibited (Liu et al., 2004; PNAS 101, 4158). Although Sdc1-/- mice are grossly normal, they are systemically smaller, suggesting that developmental abnormalities may extend further than their mammary glands. We have therefore evaluated the multi-organ response of Sdc1-/- mice to carcinogen-induced tumor development (7,12-dimethylbenz[a]anthracene, DMBA), and find these mice to be resistant to tumorigenesis in all the predominant carcinogen-susceptible lineages. Thus, Sdc1-/- mice administered DMBA during juvenile development are resistant not only to epithelial tumors, including liver (60-80%) and lung tumors (C57BL6 mice, 60-80%), but also to lymphoma (over 70%, depending upon strain and carcinogen dose). We demonstrate that CD138 is expressed (heterogeneously) in the hematopoietic stem cell fraction (and not only in pre-B and plasma cells), and that tumors arise in both myeloid and lymphoid lineages. Furthermore, carcinogen-induced mammary tumors are bilineal, implying a bipotent precursor cell. Both observations imply that the DMBA-induced tumor precursor cells are drawn from the stem/progenitor fraction, and we suggest that pathogenic activation of these cells could be abnormal in Sdc1-/- mice.

Juvenile syndecan-1 null mice are protected from carcinogen-induced tumor development. Publishing Authors By Initials

SP McDermott,EA Ranheim,VS Leatherberry,SS Khwaja,KS Klos,CM Alexander,

For similar membrane glycoproteins: syndecans: syndecan-1 research abstracts see: membrane glycoproteins: syndecans: syndecan-1 research

PUBMED ID PMID:

MEDLINE DATE:

Juvenile syndecan-1 null mice are protected from carcinogen-induced tumor development. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Oncogene

VOLUME: 26

Page Numbers: 1407-16

Journal Abbreviation: Oncogene

ISSN: 0950-9232

DAY: 4

MONTH: 09

YEAR: 2006

Juvenile syndecan-1 null mice are protected from carcinogen-induced tumor development. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8711562

Juvenile syndecan-1 null mice are protected from carcinogen-induced tumor development. Keywords Mesh Terms:

KEYWORDS: Syndecan-1

MESH TERMS: physiology

Chemical & Substance for Abstract: Juvenile syndecan-1 null mice are protected from carcinogen-induced tumor development. Information

Substance Name: 9,10-Dimethyl-1,2-benzanthracene

Registry Number: 57-97-6

Grant and Affiliation Information for Juvenile syndecan-1 null mice are protected from carcinogen-induced tumor development.

AFFILIATION: McArdle Laboratory for Cancer Research, University of Wisconsin-Madison Medical School, Madison, WI 53706, USA.

Country: England

AGENCY: United States NCI

GRANT: T32 CA09135

ACRONYM: CA

MEDLINETA: Oncogene

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Juvenile syndecan-1 null mice are protected from carcinogen-induced tumor development Related Publications

• 2006 Curt P. Richter award winner: Social influences on stress responses and health.
• A comparison of patient and physician beliefs about infrainguinal bypass operation: what role should surgical optimism play?
• A kinematic analysis of the rapid step test in balance-impaired and unimpaired older women.
• Activation of innate immunity by prostate specific antigen (PSA).
• Caveolin-dependent angiotensin II type 1 receptor signaling in vascular smooth muscle.
• Commentary.
• Comparison of the Digene Hybrid Capture System Cytomegalovirus (CMV) DNA (version 2.0), Roche CMV UL54 analyte-specific reagent, and QIAGEN RealArt CMV LightCycler PCR reagent tests using AcroMetrix OptiQuant CMV DNA quantification panels and specimens fr
• Drug use patterns in Northern Territory Aboriginal communities 1986-1987.
• Dynamic balance and stepping versus tai chi training to improve balance and stepping in at-risk older adults.
• Editorial.
• Genetic relationships between feral cattle from Chirikof Island, Alaska and other breeds.
• Guest Editorial: Outcomes in spinal cord injury.
• Hybrid diffusion imaging.
• Juvenile syndecan-1 null mice are protected from carcinogen-induced tumor development.
• Maximum step length: relationships to age and knee and hip extensor capacities.
• Orangutans use compliant branches to lower the energetic cost of locomotion.
• Outpatient rehabilitation of patients with chronic cognitive impairments after ruptured anterior communicating artery aneurysms reduces the burden of care: a pilot study.
• Prenatal influences and endothelial dysfunction: a link between reduced placental perfusion and preeclampsia.
• Proteomics of canine lymphoma identifies potential cancer-specific protein markers.
• Racial and ethnic differences in perinatal mortality: the role of fetal death.
• Relationship between the theory of planned behavior, mobility impairment and physical activity in older adults: 1951: board #21 may 31 3:30 PM - 5:00 PM.
• School employees: the forgotten municipal workers.
• Semantic and phonetic enhancements for speech-in-noise recognition by native and non-native listeners.
• Sensitive cell viability assay for use in drug screens and for studying the mechanism of action of drugs in Dictyostelium discoideum.
• Simulating mouse mammary gland development: cell ageing and its relation to stem and progenitor activity.
• Terahertz direct-contact refractometer/spectrometer.
• Testosterone contributes to marked elevations in mean arterial pressure in adult male intrauterine growth restricted offspring.
• The bath environment, the bathing task, and the older adult: a review and future directions for bathing disability research.
• Vitamin E supplementation does not improve survival from infection in mice when given after burn injury.
• Wnt signaling induces differentiation of progenitor cells in organotypic keratinocyte cultures.