Just add water: a new fluorous capping reagent for facile purification of peptides synthesized on the solid phase.

Just add water: a new fluorous capping reagent for facile purification of peptides synthesized on the solid phase. Research Abstract Details 

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Just add water: a new fluorous capping reagent for facile purification of peptides synthesized on the solid phase. Abstract Text:

Vittorio Montanari,Krishna Kumar,

A novel fluorous capping reagent is introduced to facilitate purification during solid-phase peptide synthesis (SPPS). Reagent 1 is a trivalent iodonium salt that reacts vigorously with free amines to deliver a long-chain fluoroalkyl group. It has been used to tag all unreacted amines following the peptide coupling step in SPPS. The resulting fluoroalkylated amine is no longer able to couple in further peptide coupling steps and is also stable to standard peptide synthesis conditions. Deletion products are removed using flash fluorous chromatography to yield the pure, full-length peptide.

Just add water: a new fluorous capping reagent for facile purification of peptides synthesized on the solid phase. Publishing Authors By Initials

V Montanari,K Kumar,

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Just add water: a new fluorous capping reagent for facile purification of peptides synthesized on the solid phase. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 126

Page Numbers: 9528-9

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 11

MONTH: Aug

YEAR: 2004

Just add water: a new fluorous capping reagent for facile purification of peptides synthesized on the solid phase. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Just add water: a new fluorous capping reagent for facile purification of peptides synthesized on the solid phase. Keywords Mesh Terms:

KEYWORDS: Peptides

MESH TERMS: isolation & purification

Chemical & Substance for Abstract: Just add water: a new fluorous capping reagent for facile purification of peptides synthesized on the solid phase. Information

Substance Name: Peptides

Registry Number: 0

Grant and Affiliation Information for Just add water: a new fluorous capping reagent for facile purification of peptides synthesized on the solid phase.

AFFILIATION: Department of Chemistry, Tufts University, Medford, Massachusetts 02155, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM65500

ACRONYM: GM

MEDLINETA: J Am Chem Soc

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