JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response.

JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response. Research Abstract Details 

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JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response. Abstract Text:

Jian Tao,Yunfei Gao,Ming O Li,Weifeng He,Liang Chen,Bohdan Harvev,Roger J Davis,Richard A Flavell,Zhinan Yin,

JNK1 and JNK2 have distinct effects on activation, differentiation and function of CD8+ T cells. Our early studies demonstrated that JNK1 is required for CD8+ T cell-mediated tumor immune surveillance. However, the role of JNK2 in CD8+ T cell response and effector functions, especially in anti-tumor immune response, is unknown. To define the role of JNK2 in antigen-specific immune response, we have investigated CD8+ T cells from OT-1 CD8+ transgenic mice in response to either high- or low-affinity peptides. JNK2-/- CD8+ T cells proliferated better in response to both peptides, with more cell division and less cell death. In addition, JNK2-/- CD8+ T cells produced higher levels of IFN-gamma, which is associated with increased expression of T-bet and Eomesodermin (Eomes). Moreover, JNK2-/- CD8+ T cells expresses high levels of granzyme B and show increased CTL activity. Finally, the enhanced expansion and effector function of JNK2-/- CD8+ T cells was further evidenced by their capacity to delay tumor growth in vivo. In summary, our results demonstrate that JNK2 negatively regulates antigen-specific CD8+ T cell expansion and effector function, and thus selectively blocking JNK2 in CD8+ T cells may potentially enhance anti-tumor immune response.

JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response. Publishing Authors By Initials

J Tao,Y Gao,MO Li,W He,L Chen,B Harvev,RJ Davis,RA Flavell,Z Yin,

For similar enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-serine-threonine kinases: mitogen-activated protein kinases: jnk mitogen-activated protein kinases: mitogen-activated protein kinase 9 research abstracts see: enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-serine-threonine kinases: mitogen-activated protein kinases: jnk mitogen-activated protein kinases: mitogen-activated protein kinase 9 research

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JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of immunology

VOLUME: 37

Page Numbers: 818-29

Journal Abbreviation: Eur. J. Immunol.

ISSN: 0014-2980

DAY: 3

MONTH: Mar

YEAR: 2007

JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1273201

JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response. Keywords Mesh Terms:

KEYWORDS: Mitogen-Activated Protein Kinase 9

MESH TERMS: physiology

Chemical & Substance for Abstract: JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response. Information

Substance Name: Mitogen-Activated Protein Kinase 9

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response.

AFFILIATION: Section of Rheumatology, Department of Medicine, Yale School of Medicine, New Haven, CT 06520-8031, USA.

Country: Germany

AGENCY: United States NIAID

GRANT: R01AI56219

ACRONYM: AI

MEDLINETA: Eur J Immunol

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