JNK pathway: diseases and therapeutic potential.

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JNK pathway: diseases and therapeutic potential. Abstract Text:

Jie Cui,Ming Zhang,Yong-Qing Zhang,Zhi-Heng Xu,

c-Jun N-terminal protein kinases (JNK), also known as stress-activated protein kinases, were originally identified by their ability to phosphorylate the N-terminal of the transcription factor c-Jun and by their activation in response to a variety of stresses. JNK are multifunctional kinases involved in many physiological processes. The JNK pathway has been shown to play a major role in apoptosis in many cell death paradigms and its association with a variety of pathological processes is gradually been recognized. This review will concentrate on describing the involvement of the JNK pathway in the context of different diseases and the potential to adopt the JNK pathway components as therapeutic targets.

JNK pathway: diseases and therapeutic potential. Publishing Authors By Initials

J Cui,M Zhang,YQ Zhang,ZH Xu,

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JNK pathway: diseases and therapeutic potential. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta pharmacologica Sinica

VOLUME: 28

Page Numbers: 601-8

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ISSN: 1671-4083

DAY: 18

MONTH: May

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 100956087

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AFFILIATION: Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

Country: China

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MEDLINETA: Acta Pharmacol Sin

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