Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells.

Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Research Abstract Details 

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Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Abstract Text:

Yuin-Han Loh,Weiwei Zhang,Xi Chen,Joshy George,Huck-Hui Ng,Yuin-Han Loh,Weiwei Zhang,Xi Chen,Joshy George,Huck-Hui Ng,Yuin-Han Loh,Weiwei Zhang,Xi Chen,Joshy George,Huck-Hui Ng,

Embryonic stem (ES) cells are pluripotent cells with the ability to self-renew indefinitely. These unique properties are controlled by genetic factors and chromatin structure. The exit from the self-renewing state is accompanied by changes in epigenetic chromatin modifications such as an induction in the silencing-associated histone H3 Lys 9 dimethylation and trimethylation (H3K9Me2/Me3) marks. Here, we show that the H3K9Me2 and H3K9Me3 demethylase genes, Jmjd1a and Jmjd2c, are positively regulated by the ES cell transcription factor Oct4. Interestingly, Jmjd1a or Jmjd2c depletion leads to ES cell differentiation, which is accompanied by a reduction in the expression of ES cell-specific genes and an induction of lineage marker genes. Jmjd1a demethylates H3K9Me2 at the promoter regions of Tcl1, Tcfcp2l1, and Zfp57 and positively regulates the expression of these pluripotency-associated genes. Jmjd2c acts as a positive regulator for Nanog, which encodes for a key transcription factor for self-renewal in ES cells. We further demonstrate that Jmjd2c is required to reverse the H3K9Me3 marks at the Nanog promoter region and consequently prevents transcriptional repressors HP1 and KAP1 from binding. Our results connect the ES cell transcription circuitry to chromatin modulation through H3K9 demethylation in pluripotent cells.

Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Publishing Authors By Initials

YH Loh,W Zhang,X Chen,J George,HH Ng,YH Loh,W Zhang,X Chen,J George,HH Ng,YH Loh,W Zhang,X Chen,J George,HH Ng,

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Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genes & development

VOLUME: 21

Page Numbers: 2545-57

Journal Abbreviation: Genes Dev.

ISSN: 0890-9369

DAY: 15

MONTH: Oct

YEAR: 2007

Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Information

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LANGUAGE: eng

NlmUniqueID: 8711660

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Grant and Affiliation Information for Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells.

AFFILIATION: Gene Regulation Laboratory, Genome Institute of Singapore, Singapore 138672.

Country: United States

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MEDLINETA: Genes Dev

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