JBP2, a SWI2/SNF2-like protein, regulates de novo telomeric DNA glycosylation in bloodstream form Trypanosoma brucei.

JBP2, a SWI2/SNF2-like protein, regulates de novo telomeric DNA glycosylation in bloodstream form Trypanosoma brucei. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

JBP2, a SWI2/SNF2-like protein, regulates de novo telomeric DNA glycosylation in bloodstream form Trypanosoma brucei. Abstract Text:

Rudo Kieft,Verena Brand,Dilrukshi K Ekanayake,Kate Sweeney,Courtney DiPaolo,William S Reznikoff,Robert Sabatini,

Synthesis of the modified thymine base, beta-d-glucosyl-hydroxymethyluracil or J, within telomeric DNA of Trypanosoma brucei correlates with the bloodstream form specific epigenetic silencing of telomeric variant surface glycoprotein genes involved in antigenic variation. In order to analyze the function of base J in the regulation of antigenic variation, we are characterizing the regulatory mechanism of J biosynthesis. We have recently proposed a model in which chromatin remodeling by a SWI2/SNF2-like protein (JBP2) regulates the developmental and de novo site-specific localization of J synthesis within bloodstream form trypanosome DNA. Consistent with this model, we now show that JBP2 (-/-) bloodstream form trypanosomes contain five-fold less base J and are unable to stimulate de novo J synthesis in newly generated telomeric arrays.

JBP2, a SWI2/SNF2-like protein, regulates de novo telomeric DNA glycosylation in bloodstream form Trypanosoma brucei. Publishing Authors By Initials

R Kieft,V Brand,DK Ekanayake,K Sweeney,C DiPaolo,WS Reznikoff,R Sabatini,

For similar heterocyclic compounds: heterocyclic compounds, 1-ring: pyrimidines: pyrimidinones: uracil research abstracts see: heterocyclic compounds: heterocyclic compounds, 1-ring: pyrimidines: pyrimidinones: uracil research

PUBMED ID PMID:

MEDLINE DATE:

JBP2, a SWI2/SNF2-like protein, regulates de novo telomeric DNA glycosylation in bloodstream form Trypanosoma brucei. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Molecular and biochemical parasitology

VOLUME: 156

Page Numbers: 24-31

Journal Abbreviation: Mol. Biochem. Parasitol.

ISSN: 0166-6851

DAY: 28

MONTH: 06

YEAR: 2007

JBP2, a SWI2/SNF2-like protein, regulates de novo telomeric DNA glycosylation in bloodstream form Trypanosoma brucei. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8006324

JBP2, a SWI2/SNF2-like protein, regulates de novo telomeric DNA glycosylation in bloodstream form Trypanosoma brucei. Keywords Mesh Terms:

KEYWORDS: Uracil

MESH TERMS: metabolism

Chemical & Substance for Abstract: JBP2, a SWI2/SNF2-like protein, regulates de novo telomeric DNA glycosylation in bloodstream form Trypanosoma brucei. Information

Substance Name: Uracil

Registry Number: 66-22-8

Grant and Affiliation Information for JBP2, a SWI2/SNF2-like protein, regulates de novo telomeric DNA glycosylation in bloodstream form Trypanosoma brucei.

AFFILIATION: Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.

Country: Netherlands

AGENCY: United States NIAID

GRANT: AI063523

ACRONYM: AI

MEDLINETA: Mol Biochem Parasitol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

JBP2, a SWI2/SNF2-like protein, regulates de novo telomeric DNA glycosylation in bloodstream form Trypanosoma brucei Related Publications

• Acetophenazine (Tindal) in the treatment of 80 chronically ill patients with anxiety and tension: double-blind study.
• Calcium signaling in dendrites and spines: practical and functional considerations.
• Cancer cell metabolism: warburg and beyond.
• CellProfiler: image analysis software for identifying and quantifying cell phenotypes.
• Developmental presence and disappearance of postsynaptically silent synapses on dendritic spines of rat layer 2/3 pyramidal neurons.
• Distinct structural and ionotropic roles of NMDA receptors in controlling spine and synapse stability.
• Emerging role of cytokinin as a regulator of cellular differentiation.
• Extending the traditional resection limits of squamous cell carcinoma of the anterior skull base.
• Hydrophilic-lipophilic deviation (HLD) method for characterizing conventional and extended surfactants.
• Increased mTORC1 signaling UPRegulates stress.
• JBP2, a SWI2/SNF2-like protein, regulates de novo telomeric DNA glycosylation in bloodstream form Trypanosoma brucei.
• Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway.
• Neuroscience: Neighbourly synapses.
• Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines.
• Not Available
• Recovery from amnesic confabulatory syndrome after right fornix lesion.
• Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels.
• Rhamnolipid biosurfactant mixtures for environmental remediation.
• Spectroscopic and computational studies of a Ru(II) terpyridine complex: the importance of weak intermolecular forces to photophysical properties.
• Telomeric co-localization of the modified base J and contingency genes in the protozoan parasite Trypanosoma cruzi.
• The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
• The use of chlordiazepoxide (Librium) in the alcoholic patient: a clinical study of forty cases.
• Timing and location of synaptic inputs determine modes of subthreshold integration in striatal medium spiny neurons.
• Use of a new benzodiazepine derivative (valium) in chronically ill and disturbed elderly patients.
• Voxel-based analysis of R2* maps in the healthy human brain.
• [Cutaneous lesions in man caused by virus of infectious pustular stomatitis of sheep.]
• [Dermatology and cosmetology. Dermatological legal petitions in current cosmetological practice]
• [Fisherman's dermatoses]
• [Saint's triad (esophageal hiatus hernia with cholelithiasis & diverticulosis of the colon.]
• [Therapeutic effects of chloroquine in children. In a case of malignant lupoerythemato visceritis and 2 cases of chronic rheumatism.]