Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis.

Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis. Research Abstract Details 

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Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis. Abstract Text:

Sangil Lee,Lynn Cooley,

Vesicular traffic in the Drosophila melanogaster oocyte occurs actively during vitellogenesis. Although endocytosis in the oocyte has been well characterized, exocytic vesicular traffic is less well understood. We show that the oocyte endoplasmic reticulum (ER) becomes concentrated into subcortical clusters during vitellogenesis. This ER reorganization requires Jagunal, which is an evolutionarily conserved ER membrane protein. Loss of Jagunal reduces vesicular traffic to the oocyte lateral membrane, but does not affect posterior polarized vesicular traffic, suggesting a role for Jagunal in facilitating vesicular traffic in the subcortex. Reduced membrane traffic caused by loss of Jagunal affects oocyte and bristle growth. We propose that ER reorganization is an important mechanism used by cells to prepare for an increased demand for membrane traffic, and Jagunal facilitates this process through ER clustering.

Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis. Publishing Authors By Initials

S Lee,L Cooley,

For similar animals: chordata: vertebrates: fishes: cypriniformes: cyprinidae: zebrafish research abstracts see: animals: chordata: vertebrates: fishes: cypriniformes: cyprinidae: zebrafish research

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Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of cell biology

VOLUME: 176

Page Numbers: 941-52

Journal Abbreviation: J. Cell Biol.

ISSN: 0021-9525

DAY: 26

MONTH: Mar

YEAR: 2007

Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375356

Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis. Keywords Mesh Terms:

KEYWORDS: Zebrafish

MESH TERMS: genetics

Chemical & Substance for Abstract: Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis. Information

Substance Name: jagunal protein, Drosophila

Registry Number: 0

Grant and Affiliation Information for Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis.

AFFILIATION: Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM043301

ACRONYM: GM

MEDLINETA: J Cell Biol

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