Jagged-1hi or Delta-1hi thymic stromal cell populations can trigger acquisition of Thy-1 and loss of B220.

Jagged-1hi or Delta-1hi thymic stromal cell populations can trigger acquisition of Thy-1 and loss of B220. Research Abstract Details 

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Jagged-1hi or Delta-1hi thymic stromal cell populations can trigger acquisition of Thy-1 and loss of B220. Abstract Text:

Myra Small,Myra Small,

Effects of endogenous Notch ligands Jagged-1 and Delta-1 on maturation markers in adult mouse lymphocytes were checked in vitro on putative thymocyte precursors from bone marrow and on DN3 cells from the thymus. Both populations were cocultured with stromal cells (Small M, Histochem Cell Biol 2005;123:513) naturally expressing high levels of either Jagged-1 or Delta-1. Initially the bone marrow cells were Thy-1.2(neg) while the majority were B220(hi). These trends were reversed by culture on both the Jagged-1(hi) and Delta-1(hi) monolayers. Then DN3 thymocytes were cultured with stroma expressing these two ligands and the T cell receptor beta chain was expressed more clearly after coculture on Delta-1(hi) stroma. These findings indicate that stromal cells with endogenous Jagged-1 as well as Delta-1 could initiate early changes toward T cell commitment while Delta-1 favored later alphabeta-TCR development.

Jagged-1hi or Delta-1hi thymic stromal cell populations can trigger acquisition of Thy-1 and loss of B220. Publishing Authors By Initials

M Small,M Small,

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Jagged-1hi or Delta-1hi thymic stromal cell populations can trigger acquisition of Thy-1 and loss of B220. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental and comparative immunology

VOLUME: 30

Page Numbers: 966-73

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ISSN: 0145-305X

DAY: 10

MONTH: 01

YEAR: 2006

Jagged-1hi or Delta-1hi thymic stromal cell populations can trigger acquisition of Thy-1 and loss of B220. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Jagged-1hi or Delta-1hi thymic stromal cell populations can trigger acquisition of Thy-1 and loss of B220.

AFFILIATION: Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel. msmall@post.tau.ac.il

Country: United States

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MEDLINETA: Dev Comp Immunol

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