Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis.

Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Abstract Text:

Soline Estrach,Carrie A Ambler,Cristina Lo Celso,Katsuto Hozumi,Fiona M Watt,

The Wnt and Notch signalling pathways regulate hair follicle maintenance, but how they intersect is unknown. We show that Notch signalling is active in the hair follicle pre-cortex, a region of high Wnt activity, where commitment to hair lineages occurs. Deletion of jagged 1 (Jag1) results in inhibition of the hair growth cycle and conversion of hair follicles into cysts of cells undergoing interfollicular epidermal differentiation. Conversely, activation of Notch in adult epidermis triggers expansion of the base of the hair follicle, sebaceous gland enlargement and abnormal clumping of the follicles. In adult epidermis, the induction of new hair follicle formation by beta-catenin is prevented by blocking Notch signalling pharmacologically or through Jag1 deletion. Conversely, activation of both pathways accelerates growth and differentiation of ectopic follicles. beta-catenin stimulates Notch signalling by inducing Jag1 transcription. We conclude that the Notch pathway acts downstream of the Wnt/beta-catenin pathway to determine epidermal cell fate.

Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Publishing Authors By Initials

S Estrach,CA Ambler,C Lo Celso,K Hozumi,FM Watt,

For similar proteins: armadillo domain proteins: beta catenin research abstracts see: proteins: armadillo domain proteins: beta catenin research

PUBMED ID PMID:

MEDLINE DATE:

Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Development (Cambridge, England)

VOLUME: 133

Page Numbers: 4427-38

Journal Abbreviation: Development

ISSN: 0950-1991

DAY: 11

MONTH: 10

YEAR: 2006

Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8701744

Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Keywords Mesh Terms:

KEYWORDS: beta Catenin

MESH TERMS: metabolism

Chemical & Substance for Abstract: Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Information

Substance Name: Serrate proteins

Registry Number: 134324-36-0

Grant and Affiliation Information for Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis.

AFFILIATION: Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

Country: England

AGENCY: United States NIAMS

GRANT: F32-AR049651

ACRONYM: AR

MEDLINETA: Development

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis Related Publications

• A simple benzidine test for occult blood in feces.
• Adipocyte triglyceride lipase expression in human obesity.
• Anaerobic iron deposition into horse spleen, recombinant human heavy and light and bacteria ferritins by large oxidants.
• Bone marrow edema-like lesions change in volume in the majority of patients with osteoarthritis; associations with clinical features.
• Brian harold bartlett.
• Changes in photosynthetic rates and gene expression of leaves during a source-sink perturbation in sugarcane.
• Conflicts between biodiversity conservation and human activities in the central and eastern European countries.
• Curare-modified electric convulsion therapy in cases with physical disease.
• Difference in work-related violence by nurse license type.
• Embryos and pseudoembryos: parthenotes, reprogrammed oocytes and headless clones.
• Expression of Notch pathway genes in mammalian epidermis and modulation by beta-catenin.
• First 6 months of the National Health Service.
• Fly control and the acute diarrheal diseases.
• Intravenous procaine therapy.
• Introduction of Hib vaccine into national immunization programmes: a descriptive analysis of global trends.
• Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis.
• Lipids and fatty acids of important finfish: new data for nutrient tables.
• Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier.
• Newer Procedures in Laboratory Diagnosis and Therapy in the Control of Bacillary Dysentery.
• Outbreak of Legionnaires' disease in West Fife: Review of environmental guidelines needed.
• Preservice and Inservice Preparation in Health of School Personnel-A Symposium: Role of the Department of Education and the Department of Health in the Inservice Preparation of Classroom Teachers, School Administrators, School Nurses, and School Physician
• Streamlining Hospital Techniques: Practical Implications of the Epidemiology of the Diarrheal diseases of the New-born.
• Strong corsets and pelvic congestion.
• Syntenin mediates Delta1-induced cohesiveness of epidermal stem cells in culture.
• The Acute Diarrheal Disorders.
• The KITS scheme.
• The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors.
• The murine ortholog of the SHP-2 binding molecule, PZR accelerates cell migration on fibronectin and is expressed in early embryo formation.
• The role of blood services and regulatory bodies in stem cell transplantation.
• Viral hepatitis in the Arctic. A review from a Circumpolar Workshop on Viral hepatitis, ICCH13.