Isoprenoid-independent pathway is involved in apoptosis induced by risedronate, a bisphosphonate, in which Bim plays a critical role in breast cancer cell line MCF-7.

Isoprenoid-independent pathway is involved in apoptosis induced by risedronate, a bisphosphonate, in which Bim plays a critical role in breast cancer cell line MCF-7. Research Abstract Details 

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Isoprenoid-independent pathway is involved in apoptosis induced by risedronate, a bisphosphonate, in which Bim plays a critical role in breast cancer cell line MCF-7. Abstract Text:

Keiko Suyama,Yoshihiko Noguchi,Tomoaki Tanaka,Tomohiko Yoshida,Takahisa Shibata,Yasushi Saito,Ichiro Tatsuno,Keiko Suyama,Yoshihiko Noguchi,Tomoaki Tanaka,Tomohiko Yoshida,Takahisa Shibata,Yasushi Saito,Ichiro Tatsuno,

Bisphosphonates cause apoptosis to various types of cancer cells including breast cancer. Inhibition of the mevalonate pathway was reported to be involved in the apoptosis induced by bisphosphonates, but its precise mechanism has not been unveiled. In the present study, we investigated the molecular mechanism of risedronate, a bisphosphonate, in the apoptosis of the breast cancer cell line MCF-7 in comparison with that of cerivastatin, an HMG CoA reductase inhibitor (statin), since statin has been known to induce apoptosis through an isoprenoid-dependent pathway in these cells. We found that i) risedronate induced MCF-7 cells into apoptosis in a manner similar to cerivastatin with the activation of caspase-9 followed by caspase-6 and -7, that ii) bisphosphonate-induced apoptosis was significantly, but not fully, recovered by the addition of GGOH, an isoprenoid, which completely rescued in case of cerivastatin-induced apoptosis, that iii) risedronate induced G2 arrest with the induction of Bim (BH3-only protein), but that statin induced G1 arrest without it, and that iv) the down-regulation of Bim protein by siRNA significantly attenuated the risedronate-induced apoptosis. These data clearly indicate that both isoprenoid-dependent and -independent pathways might be involved in the apoptosis induced by bisphosphonate, and Bim might be a critical component for the isoprenoid-independent apoptotic pathway.

Isoprenoid-independent pathway is involved in apoptosis induced by risedronate, a bisphosphonate, in which Bim plays a critical role in breast cancer cell line MCF-7. Publishing Authors By Initials

K Suyama,Y Noguchi,T Tanaka,T Yoshida,T Shibata,Y Saito,I Tatsuno,K Suyama,Y Noguchi,T Tanaka,T Yoshida,T Shibata,Y Saito,I Tatsuno,

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Isoprenoid-independent pathway is involved in apoptosis induced by risedronate, a bisphosphonate, in which Bim plays a critical role in breast cancer cell line MCF-7. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Oncology reports

VOLUME: 18

Page Numbers: 1291-8

Journal Abbreviation: Oncol. Rep.

ISSN: 1021-335X

DAY: 4

MONTH: Nov

YEAR: 2007

Isoprenoid-independent pathway is involved in apoptosis induced by risedronate, a bisphosphonate, in which Bim plays a critical role in breast cancer cell line MCF-7. Information

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LANGUAGE: eng

NlmUniqueID: 9422756

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Grant and Affiliation Information for Isoprenoid-independent pathway is involved in apoptosis induced by risedronate, a bisphosphonate, in which Bim plays a critical role in breast cancer cell line MCF-7.

AFFILIATION: Department of Clinical Cell Biology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.

Country: Greece

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MEDLINETA: Oncol Rep

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