Isoprenoid biosynthesis via the mevalonate-independent route, a novel target for antibacterial drugs?

Isoprenoid biosynthesis via the mevalonate-independent route, a novel target for antibacterial drugs? Research Abstract Details 

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Isoprenoid biosynthesis via the mevalonate-independent route, a novel target for antibacterial drugs? Abstract Text:

Mevalonate was accepted as the universal precursor of all isoprenoids. This assertion was however revealed to be partially incorrect. Incorporation of 13C labeled acetate and glucose into bacterial triterpenoids of the hopane series allowed for the discovery and the partial elucidation of a novel biosynthetic pathway leading to isopentenyl diphosphate. The C5 skeleton of isoprenic units results from the condensation of (hydroxyethyl)thiamin on the carbonyl group of glyceraldehyde 3-phosphate, yielding D-1-deoxyxylulose 1-phosphate. A subsequent intramolecular rearrangement is involved in the formation of the branched isoprenic skeleton. 2C-Methyl-D-erythritol (or its mono- or diphosphate) was shown to be a putative intermediate. This pathway is widespread in bacteria including opportunistic pathogens or innocuous species related to well-known pathogens. In plants, it is involved in the formation of essential chloroplast isoprenoids (carotenoids, phytol, plastoquinone) and of probably most other plastid related isoprenoids of more restricted distribution (isoprene, mono- and diterpenoids). Therefore it potentially represents a novel target for antibacterial drugs and herbicides.

Isoprenoid biosynthesis via the mevalonate-independent route, a novel target for antibacterial drugs? Publishing Authors By Initials

For similar organic chemicals: organophosphorus compounds research abstracts see: organic chemicals: organophosphorus compounds research

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Isoprenoid biosynthesis via the mevalonate-independent route, a novel target for antibacterial drugs? Journal Published:

PUBLICATION TYPE: Review

Journal: Progress in drug research. Fortschritte der Arznei

VOLUME: 50

Page Numbers: 135-54

Journal Abbreviation:

ISSN: 0071-786X

DAY: 25

MONTH: 02

YEAR: 1998

Isoprenoid biosynthesis via the mevalonate-independent route, a novel target for antibacterial drugs? Information

Number of References: 73

LANGUAGE: eng

NlmUniqueID: 1304021

Isoprenoid biosynthesis via the mevalonate-independent route, a novel target for antibacterial drugs? Keywords Mesh Terms:

KEYWORDS: Organophosphorus Compounds

MESH TERMS: metabolism

Chemical & Substance for Abstract: Isoprenoid biosynthesis via the mevalonate-independent route, a novel target for antibacterial drugs? Information

Substance Name: isopentenyl pyrophosphate

Registry Number: 358-71-4

Grant and Affiliation Information for Isoprenoid biosynthesis via the mevalonate-independent route, a novel target for antibacterial drugs?

AFFILIATION: Université Louis Pasteur CNRS, Institut Le Bel, Strasbourg, France.

Country: SWITZERLAND

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MEDLINETA: Prog Drug Res

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