Isolation of avian paramyxovirus 1 from a patient with a lethal case of pneumonia.

Isolation of avian paramyxovirus 1 from a patient with a lethal case of pneumonia. Research Abstract Details 

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Isolation of avian paramyxovirus 1 from a patient with a lethal case of pneumonia. Abstract Text:

Scott J Goebel,Jill Taylor,Bradd C Barr,Timothy E Kiehn,Hugo R Castro-Malaspina,Cyrus V Hedvat,Kim A Rush-Wilson,Cassandra D Kelly,Stephen W Davis,William A Samsonoff,Kelley R Hurst,Melissa J Behr,Paul S Masters,Scott J Goebel,Jill Taylor,Bradd C Barr,Timothy E Kiehn,Hugo R Castro-Malaspina,Cyrus V Hedvat,Kim A Rush-Wilson,Cassandra D Kelly,Stephen W Davis,William A Samsonoff,Kelley R Hurst,Melissa J Behr,Paul S Masters,

An unknown virus was isolated from a lung biopsy sample and multiple other samples from a patient who developed a lethal case of pneumonia following a peripheral blood stem cell transplant. A random PCR-based molecular screening method was used to identify the infectious agent as avian paramyxovirus 1 (APMV-1; a group encompassing Newcastle disease virus), which is a highly contagious poultry pathogen that has only rarely been found in human infections. Immunohistochemical analysis confirmed the presence of APMV-1 antigen in sloughed alveolar cells in lung tissue from autopsy. Sequence from the human isolate showed that it was most closely related to virulent pigeon strains of APMV-1. This is the most completely documented case of a systemic human infection caused by APMV-1 and is the first report of an association between this virus and a fatal disease in a human.

Isolation of avian paramyxovirus 1 from a patient with a lethal case of pneumonia. Publishing Authors By Initials

SJ Goebel,J Taylor,BC Barr,TE Kiehn,HR Castro-Malaspina,CV Hedvat,KA Rush-Wilson,CD Kelly,SW Davis,WA Samsonoff,KR Hurst,MJ Behr,PS Masters,SJ Goebel,J Taylor,BC Barr,TE Kiehn,HR Castro-Malaspina,CV Hedvat,KA Rush-Wilson,CD Kelly,SW Davis,WA Samsonoff,KR Hurst,MJ Behr,PS Masters,

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Isolation of avian paramyxovirus 1 from a patient with a lethal case of pneumonia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of virology

VOLUME: 81

Page Numbers: 12709-14

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 12

MONTH: 09

YEAR: 2007

Isolation of avian paramyxovirus 1 from a patient with a lethal case of pneumonia. Information

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LANGUAGE: eng

NlmUniqueID: 113724

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AFFILIATION: Divisions of Infectious Disease and Molecular Medicine, David Axelrod Institute, Wadsworth Center, NYSDOH, Albany, NY 12201-2002, USA.

Country: United States

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MEDLINETA: J Virol

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