Isolation from human erythrocytes of a new membrane protein which inhibits the formation of complement transmembrane channels.

Isolation from human erythrocytes of a new membrane protein which inhibits the formation of complement transmembrane channels. Research Abstract Details 

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Isolation from human erythrocytes of a new membrane protein which inhibits the formation of complement transmembrane channels. Abstract Text:

Y Sugita,Y Nakano,M Tomita,

A protein which inhibited complement channel formation was isolated from extracts of papain-digested human erythrocyte membranes using DEAE-Sephacel, Bio-Gel A0.5m column chromatographies, and preparative sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by transfer to nitrocellulose paper and elution with 2% NP-40 solution. The purified protein showed a molecular weight of 18 kDa, and efficiently inhibited hemolysis of EC5-7 cells with C8 and C9, but did not show any decay-accelerating activity to C5 convertase. Immunochemical analysis of native membranes after sodium dodecyl sulfate-polyacrylamide gel electrophoresis using the antibody against this protein gave a single band having the same mobility as this protein; papain did not eliminate a significant portion of this protein.

Isolation from human erythrocytes of a new membrane protein which inhibits the formation of complement transmembrane channels. Publishing Authors By Initials

Y Sugita,Y Nakano,M Tomita,

For similar proteins: membrane proteins research abstracts see: proteins: membrane proteins research

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Isolation from human erythrocytes of a new membrane protein which inhibits the formation of complement transmembrane channels. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 104

Page Numbers: 633-7

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Oct

YEAR: 1988

Isolation from human erythrocytes of a new membrane protein which inhibits the formation of complement transmembrane channels. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Isolation from human erythrocytes of a new membrane protein which inhibits the formation of complement transmembrane channels. Keywords Mesh Terms:

KEYWORDS: Membrane Proteins

MESH TERMS: isolation & purification

Chemical & Substance for Abstract: Isolation from human erythrocytes of a new membrane protein which inhibits the formation of complement transmembrane channels. Information

Substance Name: Complement System Proteins

Registry Number: 9007-36-7

Grant and Affiliation Information for Isolation from human erythrocytes of a new membrane protein which inhibits the formation of complement transmembrane channels.

AFFILIATION: Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo.

Country: JAPAN

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MEDLINETA: J Biochem

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