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Isolation, characterization, and expression analysis of zebrafish large Mafs.

Isolation, characterization, and expression analysis of zebrafish large Mafs. Research Abstract Details 

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  • Isolation, characterization, and expression analysis of zebrafish large Mafs. Abstract Text:

    m kajiharaM Kajihara,s kawauchiS Kawauchi,m kobayashiM Kobayashi,h oginoH Ogino,s takahashiS Takahashi,k yasudaK Yasuda,

    Large Maf proteins, which are members of the basic leucine zipper (b-Zip) superfamily, are involved in the determination and control of cellular differentiation. The expression patterns of various vertebrate large Maf mRNAs were described previously. Here, we report the cloning of a novel zebrafish large Maf cDNA, SMaf1 (Somite Maf1), and other zebrafish large Mafs, the N-terminus domains of which possess transactivational activity. We also analyzed the expression patterns of SMaf1 and SMaf2 (Somite Maf2)/Krml2 as well as MafB/Val and c-Maf during zebrafish embryogenesis. In particular, the robust expression of the novel SMaf1 mRNA, which overlapped that of MyoD, in somitic cells during somitogenesis was noteworthy. In addition, the expression patterns of SMaf2 and MafB in the blood-forming regions, and those of c-Maf and MafB in the lens cells showed spatial redundancy, although the temporal appearance of these genes at these sites differed. These data indicate that SMafs may play important roles in somitogenesis, and that Maf proteins may have overlapping and yet specific functions as to the determination and differentiation of cell lineages.

    Isolation, characterization, and expression analysis of zebrafish large Mafs. Publishing Authors By Initials

    m kajiharaM Kajihara,s kawauchiS Kawauchi,m kobayashiM Kobayashi,h oginoH Ogino,s takahashiS Takahashi,k yasudaK Yasuda,

    For similar proteins: fish proteins: zebrafish proteins research abstracts see: proteins: fish proteins: zebrafish proteins research

    PUBMED ID PMID:

    MEDLINE DATE:

    Isolation, characterization, and expression analysis of zebrafish large Mafs. Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: Journal of biochemistry

    VOLUME: 129

    Page Numbers: 139-46

    Journal Abbreviation: J. Biochem.

    ISSN: 0021-924X

    DAY: 19

    MONTH: Jan

    YEAR: 2001

    Isolation, characterization, and expression analysis of zebrafish large Mafs. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 376600

    Isolation, characterization, and expression analysis of zebrafish large Mafs. Keywords Mesh Terms:

    KEYWORDS: Zebrafish Proteins

    MESH TERMS: physiology

    Chemical & Substance for Abstract: Isolation, characterization, and expression analysis of zebrafish large Mafs. Information

    Substance Name: mafl protein, zebrafish

    Registry Number: 0

    Grant and Affiliation Information for Isolation, characterization, and expression analysis of zebrafish large Mafs.

    AFFILIATION: Institute of Basic Medical Sciences, University of Tsukuba, Tennodai, Tsukuba 305-8575, Japan.

    Country: Japan

    Japan Research PublicationJapan Research Publication

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    ACRONYM:

    MEDLINETA: J Biochem

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