Isolation and structural identification of an impurity in fluconazole bulk drug substance.

Isolation and structural identification of an impurity in fluconazole bulk drug substance. Research Abstract Details 

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Isolation and structural identification of an impurity in fluconazole bulk drug substance. Abstract Text:

Vaijanath G Dongre,Pradeep D Ghugare,Pravin P Karmuse,Satish R Soudagar,Nalinakshya Panda,Ashok Kumar,Vaijanath G Dongre,Pradeep D Ghugare,Pravin P Karmuse,Satish R Soudagar,Nalinakshya Panda,Ashok Kumar,

Four impurities in fluconazole API sample obtained from a recently proposed synthetic process were detected by HPLC. One of the impurities was unknown having not been reported previously. This less polar unknown impurity was isolated from the crude sample of fluconazole bulk drug using semi-preparative HPLC. Structure of impurity was elucidated as 2-(2-(dimethylamino)-4-fluorophenyl)-1,3-di(3H-1,2,4-triazol-1-yl)propan-2-ol by using NMR spectroscopy((1)H, (13)C, (19)F, (1)H-(1)H, (1)H-(13)C, HMBC and nOe) and mass spectrometry. The formation and synthesis of the impurity was discussed.

Isolation and structural identification of an impurity in fluconazole bulk drug substance. Publishing Authors By Initials

VG Dongre,PD Ghugare,PP Karmuse,SR Soudagar,N Panda,A Kumar,VG Dongre,PD Ghugare,PP Karmuse,SR Soudagar,N Panda,A Kumar,

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Isolation and structural identification of an impurity in fluconazole bulk drug substance. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of pharmaceutical and biomedical analysis

VOLUME: 45

Page Numbers: 422-9

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ISSN: 0731-7085

DAY: 10

MONTH: 07

YEAR: 2007

Isolation and structural identification of an impurity in fluconazole bulk drug substance. Information

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LANGUAGE: eng

NlmUniqueID: 8309336

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Grant and Affiliation Information for Isolation and structural identification of an impurity in fluconazole bulk drug substance.

AFFILIATION: Department of Chemistry, University of Mumbai, Vidyanagari, Kalina, Santacruz (East), Mumbai 400098, India.

Country: England

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MEDLINETA: J Pharm Biomed Anal

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