Isolation and identification of impurities in chlorin e6.

Isolation and identification of impurities in chlorin e6. Research Abstract Details 

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Isolation and identification of impurities in chlorin e6. Abstract Text:

H A Isakau,T V Trukhacheva,P T Petrov,

The tetrapyrrolic compound chlorin e6 is currently used as a pharmaceutical substance for Photolon formulation, which is utilized in photodynamic therapy of various diseases. It was found that chlorin e6 could contain both process- and degradation-related impurities. In order to understand their origin, the most abundant impurities were prepared by liquid extraction, preparative chromatography or chemical synthesis. By means of HPLC-PDA-MS, 1D and 2D NMR spectroscopy, these impurities were identified as chlorin e6 17(4)-ethyl ester, chlorin e4, 15-hydroxyphyllochlorin, rhodochlorin, 15(1)-hydroxymethylrhodochlorin delta-lactone, rhodochlorin-15-oxymethyl delta-lactone, rhodochlorin-15-oxymethyl delta-lactone 17(4)-ethyl ester, 15(1)-hydroxymethylrhodoporphyrin delta-lactone, rhodoporphyrin-15-oxymethyl delta-lactone and purpurin 18. The possible routes of formation of the chlorin derivatives upon the production and storage of chlorin e6 are discussed.

Isolation and identification of impurities in chlorin e6. Publishing Authors By Initials

HA Isakau,TV Trukhacheva,PT Petrov,

For similar chemical actions and uses: pharmacologic actions: physiological effects of drugs: radiation-sensitizing agents research abstracts see: chemical actions and uses: pharmacologic actions: physiological effects of drugs: radiation-sensitizing agents research

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Isolation and identification of impurities in chlorin e6. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of pharmaceutical and biomedical analysis

VOLUME: 45

Page Numbers: 20-9

Journal Abbreviation:

ISSN: 0731-7085

DAY: 21

MONTH: 05

YEAR: 2007

Isolation and identification of impurities in chlorin e6. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8309336

Isolation and identification of impurities in chlorin e6. Keywords Mesh Terms:

KEYWORDS: Radiation-Sensitizing Agents

MESH TERMS: isolation & purification

Chemical & Substance for Abstract: Isolation and identification of impurities in chlorin e6. Information

Substance Name: chlorin e6

Registry Number: 19660-77-6

Grant and Affiliation Information for Isolation and identification of impurities in chlorin e6.

AFFILIATION: Scientific Pharmaceutical Center, RUE Belmedpreparaty, Fabritsius Str. 30, Minsk 220007, Belarus.

Country: England

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MEDLINETA: J Pharm Biomed Anal

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