Isolation and characterization of a novel protein toxin from fire coral.

Isolation and characterization of a novel protein toxin from fire coral. Research Abstract Details 

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Isolation and characterization of a novel protein toxin from fire coral. Abstract Text:

Akiko Iguchi,Setsuko Iwanaga,Hiroshi Nagai,Akiko Iguchi,Setsuko Iwanaga,Hiroshi Nagai,

Fire corals (Millepora spp.) cause severe pain and inflammatory effects in humans upon contact, and the organs responsible for these effects are called nematocysts. Here, we isolated an active cytotoxin of ca. 18 kDa (MCTx-1) from nematocysts of Millepora dichotoma var. tenera. MCTx-1 was potently cytotoxic (EC50 value 79 ng/mL) towards L1210 mouse leukemia cells, hemagglutinated a 0.8% suspension of sheep erythrocytes (0.2 microg protein/mL) and was lethal in crayfish (LD50, 106 microg/kg). We deduced the primary structure of MCTx-1 from the corresponding cDNA sequence and found that MCTx-1 is a novel dermatopontin that is an extracellular matrix protein in mammals. This is the first characterization of a proteinaceous toxin from fire coral.

Isolation and characterization of a novel protein toxin from fire coral. Publishing Authors By Initials

A Iguchi,S Iwanaga,H Nagai,A Iguchi,S Iwanaga,H Nagai,

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Isolation and characterization of a novel protein toxin from fire coral. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 365

Page Numbers: 107-12

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 1090-2104

DAY: 5

MONTH: 11

YEAR: 2007

Isolation and characterization of a novel protein toxin from fire coral. Information

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LANGUAGE: eng

NlmUniqueID: 372516

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Grant and Affiliation Information for Isolation and characterization of a novel protein toxin from fire coral.

AFFILIATION: Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato-ku, Tokyo 108-8477, Japan.

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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