Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia.

Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. Research Abstract Details 

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Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. Abstract Text:

Zhongcong Xie,Yuanlin Dong,Uta Maeda,Robert Moir,Sharon K Inouye,Deborah J Culley,Gregory Crosby,Rudolph E Tanzi,

BACKGROUND: Dementia and delirium have been postulated to share common pathophysiologic mechanisms; however, identification of these unifying mechanisms has remained elusive. The inhalation anesthetic isoflurane has been shown to enhance beta-amyloid protein (Abeta) oligomerization and generation, to potentiate the cytotoxicity of Abeta, and to induce apoptosis. To address the molecular mechanisms of dementia and delirium associated with anesthesia and surgery, we assessed whether the Abeta fibrillar aggregation inhibitor Congo red can attenuate isoflurane-induced caspase-3 activation in H4 human neuroglioma cells overexpressing human beta-amyloid precursor protein (APP). METHODS: H4 human neuroglioma cells stably transfected to express human full-length wild-type APP were exposed to 2% isoflurane for 6 hours. The cells were harvested at the end of the treatment. Caspase-3 activation was measured with quantitative Western blotting. RESULTS: We found that isoflurane induces cellular apoptosis in a dose-dependent manner, and that Congo red inhibits isoflurane-induced apoptosis in H4 human neuroglioma cells overexpressing APP. Interestingly, Congo red also inhibits staurosporine-induced apoptosis. CONCLUSION: The demonstration that isoflurane contributes to well-described mechanisms of Alzheimer's neuropathogenesis provides a plausible link between the acute effects of anesthesia, a well-described risk factor for delirium, and the more long-term sequelae of dementia. These findings suggest that isoflurane-induced Abeta oligomerization and apoptosis may contribute to the risk of postoperative cognitive dysfunction and provide a potential pathogenic link between delirium and dementia.

Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. Publishing Authors By Initials

Z Xie,Y Dong,U Maeda,R Moir,SK Inouye,DJ Culley,G Crosby,RE Tanzi,

For similar nervous system: neuroglia research abstracts see: nervous system: neuroglia research

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Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The journals of gerontology. Series A, Biological

VOLUME: 61

Page Numbers: 1300-6

Journal Abbreviation: J. Gerontol. A Biol. Sci. Med.

ISSN: 1079-5006

DAY: 3

MONTH: Dec

YEAR: 2006

Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9502837

Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. Keywords Mesh Terms:

KEYWORDS: Neuroglia

MESH TERMS: drug effects

Chemical & Substance for Abstract: Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. Information

Substance Name: Isoflurane

Registry Number: 26675-46-7

Grant and Affiliation Information for Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia.

AFFILIATION: Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129-4404, USA.

Country: United States

AGENCY: United States NIA

GRANT: R21AG025193

ACRONYM: AG

MEDLINETA: J Gerontol A Biol Sci Med Sci

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