Islet inflammation in type 2 diabetes: from metabolic stress to therapy.

Islet inflammation in type 2 diabetes: from metabolic stress to therapy. Research Abstract Details 

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Islet inflammation in type 2 diabetes: from metabolic stress to therapy. Abstract Text:

Marc Y Donath,Desiree M Schumann,Mirjam Faulenbach,Helga Ellingsgaard,Aurel Perren,Jan A Ehses,Marc Y Donath,Desiree M Schumann,Mirjam Faulenbach,Helga Ellingsgaard,Aurel Perren,Jan A Ehses,

Decreases in both mass and secretory function of insulin-producing beta-cells contribute to the pathophysiology of type 2 diabetes. The histology of islets from patients with type 2 diabetes displays an inflammatory process characterized by the presence of cytokines, apoptotic cells, immune cell infiltration, amyloid deposits, and eventually fibrosis. This inflammatory process is probably the combined consequence of dyslipidemia, hyperglycemia, and increased circulating adipokines. Therefore, modulation of intra-islet inflammatory mediators, in particular interleukin-1 beta, appears as a promising therapeutic approach.

Islet inflammation in type 2 diabetes: from metabolic stress to therapy. Publishing Authors By Initials

MY Donath,DM Schumann,M Faulenbach,H Ellingsgaard,A Perren,JA Ehses,MY Donath,DM Schumann,M Faulenbach,H Ellingsgaard,A Perren,JA Ehses,

For similar digestive system diseases: pancreatic diseases research abstracts see: digestive system diseases: pancreatic diseases research

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Islet inflammation in type 2 diabetes: from metabolic stress to therapy. Journal Published:

PUBLICATION TYPE: Review

Journal: Diabetes care

VOLUME: 31 Suppl 2

Page Numbers: S161-4

Journal Abbreviation: Diabetes Care

ISSN: 1935-5548

DAY: 28

MONTH: Feb

YEAR: 2008

Islet inflammation in type 2 diabetes: from metabolic stress to therapy. Information

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LANGUAGE: eng

NlmUniqueID: 7805975

Islet inflammation in type 2 diabetes: from metabolic stress to therapy. Keywords Mesh Terms:

KEYWORDS: Pancreatic Diseases

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Islet inflammation in type 2 diabetes: from metabolic stress to therapy. Information

Substance Name: Glucose

Registry Number: 50-99-7

Grant and Affiliation Information for Islet inflammation in type 2 diabetes: from metabolic stress to therapy.

AFFILIATION: Clinic of Endocrinology and Diabetes, Department of Medicine, University Hospital, CH-8091 Zurich, Switzerland. marc.donath@usz.ch

Country: United States

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MEDLINETA: Diabetes Care

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