Ischemic rat brain extracts induce human marrow stromal cell growth factor production.

Ischemic rat brain extracts induce human marrow stromal cell growth factor production. Research Abstract Details 

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Ischemic rat brain extracts induce human marrow stromal cell growth factor production. Abstract Text:

Intravenous administration of human bone marrow stromal cells (hMSCs) after middle cerebral artery occlusion (MCAo) in rats provides functional benefit. We tested the hypothesis that these functional benefits are derived in part from hMSC production of growth and trophic factors. Quantitative sandwich enzyme-linked immunosorbent assay (ELISA) of hMSCs cultured with normal and MCAo brain extracts were performed. hMSCs cultured in supernatant derived from ischemic brain extracts increased production of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF). These neurotrophins and angiogenic growth factors increased in a post-ischemia time-dependent manner. The hMSC capacity to increase expression of growth and trophic factors may be the key to the benefit provided by transplanted hMSCs in the ischemic brain.

Ischemic rat brain extracts induce human marrow stromal cell growth factor production. Publishing Authors By Initials

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Ischemic rat brain extracts induce human marrow stromal cell growth factor production. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Neuropathology : official journal of the Japanese

VOLUME: 22

Page Numbers: 275-9

Journal Abbreviation: Neuropathology

ISSN: 0919-6544

DAY: 10

MONTH: Dec

YEAR: 2002

Ischemic rat brain extracts induce human marrow stromal cell growth factor production. Information

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LANGUAGE: eng

NlmUniqueID: 9606526

Ischemic rat brain extracts induce human marrow stromal cell growth factor production. Keywords Mesh Terms:

KEYWORDS: Tissue Extracts

MESH TERMS: pharmacology

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Substance Name: Tissue Extracts

Registry Number: 0

Grant and Affiliation Information for Ischemic rat brain extracts induce human marrow stromal cell growth factor production.

AFFILIATION: Department of Neurology, Division of Hematology/Medical Oncology, Henry Ford Health Sciences Center, Detroit, USA.

Country: Australia

AGENCY: United States NINDS

GRANT: P01 NS23393

ACRONYM: NS

MEDLINETA: Neuropathology

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